641-77-0
Chemical Structure
21-Deoxycortisol
- CAS No.: 641-77-0
- Formula:C21H30O4
- Molecular Weight:346.47
IUPAC Name: (8S,9S,10R,11S,13S,14S,17R)-17-acetyl-11,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
InChIKey: LCZBQMKVFQNSJR-UJPCIWJBSA-N
SMILES: C[C@]1(C2)[C@](CC[C@@]1(C(C)=O)O)([H])[C@@](CC3)([H])[C@@]([C@H]2O)([H])[C@](CC4)(C)C3=CC4=O
Biological Activity: 21-Deoxycortisol is an adrenal-specific C21 steroid that accumulates via alternative pathways due to 21-hydroxylase (CYP21A2/P450c21) deficiency. 21-Deoxycortisol serves as a sensitive and specific biomarker for steroid 21-hydroxylase deficiency (21OHD)[1][2].
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21-Deoxycortisol | 99.49% | 21-Deoxycortisol is an adrenal-specific C21 steroid that accumulates via alternative pathways due to 21-hydroxylase (CYP21A2/P450c21) deficiency. 21-Deoxycortisol serves as a sensitive and specific biomarker for steroid 21-hydroxylase deficiency (21OHD). | ||||||||||||||||||||
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21-Deoxycortisol (Standard) | ≥98% | 21-Deoxycortisol (Standard) is the analytical standard of 21-Deoxycortisol (HY-113405). This product is intended for research and analytical applications. 21-Deoxycortisol is an adrenal-specific C21 steroid that accumulates via alternative pathways due to 21-hydroxylase (CYP21A2/P450c21) deficiency. 21-Deoxycortisol serves as a sensitive and specific biomarker for steroid 21-hydroxylase deficiency (21OHD). | ||||||||||||||||||||
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21-Deoxycortisol-d8 | 98.79% | 21-Deoxycortisol-d8 is the d8-labeled 21-Deoxycortisol (HY-113405). 21-Deoxycortisol is an adrenal-specific C21 steroid that accumulates via alternative pathways due to 21-hydroxylase (CYP21A2/P450c21) deficiency. 21-Deoxycortisol serves as a sensitive and specific biomarker for steroid 21-hydroxylase deficiency (21OHD). | ||||||||||||||||||||
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21-Desoxycortisol-d4 | 21-Desoxycortisol-d4 is the d4-labeled 21-Deoxycortisol (HY-113405). 21-Deoxycortisol is an adrenal-specific C21 steroid that accumulates via alternative pathways due to 21-hydroxylase (CYP21A2/P450c21) deficiency. 21-Deoxycortisol serves as a sensitive and specific biomarker for steroid 21-hydroxylase deficiency (21OHD). | |||||||||||||||||||||
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References
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[1]. Miller WL. Congenital Adrenal Hyperplasia: Time to Replace 17OHP with 21-Deoxycortisol. Horm Res Paediatr. 2019;91(6):416-420.
[Content Brief] - [2]. Ng JL, et al. Serum 21-Deoxycortisol for Diagnosis of Nonclassic Congenital Adrenal Hyperplasia in Women With Androgen Excess. The Journal of clinical endocrinology and metabolism. 2023 Nov 17;108(12):e1560-e1570. [Content Brief]
