641-77-0
641-77-0
Chemical Structure
21-Deoxycortisol
- CAS No.: 641-77-0
- Formula:C21H30O4
- Molecular Weight:346.47
IUPAC Name: (8S,9S,10R,11S,13S,14S,17R)-17-acetyl-11,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
InChIKey: LCZBQMKVFQNSJR-UJPCIWJBSA-N
SMILES: C[C@]1(C2)[C@](CC[C@@]1(C(C)=O)O)([H])[C@@](CC3)([H])[C@@]([C@H]2O)([H])[C@](CC4)(C)C3=CC4=O
Biological Activity: 21-Deoxycortisol is an adrenal-specific C21 steroid that accumulates via alternative pathways due to 21-hydroxylase (CYP21A2/P450c21) deficiency. 21-Deoxycortisol serves as a sensitive and specific biomarker for steroid 21-hydroxylase deficiency (21OHD)[1][2].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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21-Deoxycortisol | 99.49% | 21-Deoxycortisol is an adrenal-specific C21 steroid that accumulates via alternative pathways due to 21-hydroxylase (CYP21A2/P450c21) deficiency. 21-Deoxycortisol serves as a sensitive and specific biomarker for steroid 21-hydroxylase deficiency (21OHD). | ||||||||||||||||||||
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21-Deoxycortisol (Standard) | ≥98% | 21-Deoxycortisol (Standard) is the analytical standard of 21-Deoxycortisol (HY-113405). This product is intended for research and analytical applications. 21-Deoxycortisol is an adrenal-specific C21 steroid that accumulates via alternative pathways due to 21-hydroxylase (CYP21A2/P450c21) deficiency. 21-Deoxycortisol serves as a sensitive and specific biomarker for steroid 21-hydroxylase deficiency (21OHD). | ||||||||||||||||||||
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21-Deoxycortisol-d8 | 98.79% | 21-Deoxycortisol-d8 is the d8-labeled 21-Deoxycortisol (HY-113405). 21-Deoxycortisol is an adrenal-specific C21 steroid that accumulates via alternative pathways due to 21-hydroxylase (CYP21A2/P450c21) deficiency. 21-Deoxycortisol serves as a sensitive and specific biomarker for steroid 21-hydroxylase deficiency (21OHD). | ||||||||||||||||||||
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21-Desoxycortisol-d4 | 21-Desoxycortisol-d4 is the d4-labeled 21-Deoxycortisol (HY-113405). 21-Deoxycortisol is an adrenal-specific C21 steroid that accumulates via alternative pathways due to 21-hydroxylase (CYP21A2/P450c21) deficiency. 21-Deoxycortisol serves as a sensitive and specific biomarker for steroid 21-hydroxylase deficiency (21OHD). | |||||||||||||||||||||
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17α-Hydroxyprogesterone (Standard) | 99.78% | 17α-Hydroxyprogesterone (Standard) is the analytical standard of 17α-Hydroxyprogesterone. This product is intended for research and analytical applications. | ||||||||||||||||||||
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17α-Hydroxyprogesterone-13C3 | 17α-Hydroxyprogesterone-13C3 is the 13C-labeled 17α-Hydroxyprogesterone. 17α-Hydroxyprogesterone (17-Hydroxyprogesterone) is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens. | |||||||||||||||||||||
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Hydrocortisone acetate | 99.07% | Hydrocortisone acetate (Hydrocortisone 21-acetate) is a corticosteroid used to reduce swelling, itching and pain caused by minor skin irritations or hemorrhoids. |
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Hydrocortisone | 99.92% | Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex. | ||||||||||||||||||||
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11β-Hydroxy-17α-methyltestosterone | 11β-Hydroxy-17α-methyltestosterone is a metabolite of 17α-methyltestosterone. | |||||||||||||||||||||
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Hydrocortisone aceate impurity 1 | Hydrocortisone aceate impurity 1 is an impurity of Hydrocortisone aceate. | |||||||||||||||||||||
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21-Deoxy cortisone | 99.5% | 21-Deoxycortisone (21-Desoxycortisone; NSC 38722) is an endogenous C21 pregnane steroid metabolite. 21-Deoxycortisone is a substrate for 21-hydroxylation in calf adrenal glands and can be converted to Cortisone (HY-17461). 21-Deoxycortisone can be used for metabolism-related research. | ||||||||||||||||||||
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Deprodone | 98.0% | Deprodone is an active compound. Deprodone inhibits key processes such as bacterial cell wall synthesis by interacting with the hydrolase and transferase proteins of methicillin-resistant Staphylococcus aureus (MRSA). Deprodone is used in research on anti-MRSA infection, inflammatory skin disorders, bowel disease, and fatty acid metabolism disorders. | ||||||||||||||||||||
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Hydrocortisone impurity 6 | Hydrocortisone impurity 6 (21-Dehydrocortisol) is an impurity of Hydrocortisone. | |||||||||||||||||||||
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Hydrocortisone impurity 9 | Hydrocortisone impurity 9 is an impurity of Hydrocortisone. | |||||||||||||||||||||
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References
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[1]. Miller WL. Congenital Adrenal Hyperplasia: Time to Replace 17OHP with 21-Deoxycortisol. Horm Res Paediatr. 2019;91(6):416-420.
[Content Brief] - [2]. Ng JL, et al. Serum 21-Deoxycortisol for Diagnosis of Nonclassic Congenital Adrenal Hyperplasia in Women With Androgen Excess. The Journal of clinical endocrinology and metabolism. 2023 Nov 17;108(12):e1560-e1570. [Content Brief]
