64232-83-3
64232-83-3
Chemical Structure
L189
- CAS No.: 64232-83-3
- Formula:C11H10N4OS
- Molecular Weight:246.29
IUPAC Name: (E)-6-amino-5-(benzylideneamino)-2-mercaptopyrimidin-4-ol
InChIKey: SAKOXVNKDMWWLF-AWNIVKPZSA-N
SMILES: OC1=NC(S)=NC(N)=C1/N=C/C2=CC=CC=C2
Biological Activity: L189 is a DNA ligase inhibitor. L189 has inhibition effect for DNA Ligase I, III and IV with IC50 values of 5 μM, 9 μM and 5 μM, respectively. L189 has no cytotoxicity and individually increase cell death. L189 can be used for the research of cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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L189 | 98.0% | L189 is a DNA ligase inhibitor. L189 has inhibition effect for DNA Ligase I, III and IV with IC50 values of 5 μM, 9 μM and 5 μM, respectively. L189 has no cytotoxicity and individually increase cell death. L189 can be used for the research of cancer. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.59
HY-42593(E)-4,6-dichloro-2-styrylpyrimidine -
Similarity Score 0.58
HY-139782SKLB325 -
Similarity Score 0.58
HY-B0985Phenazopyridine hydrochloride -
Similarity Score 0.57
HY-B0985APhenazopyridine -
Similarity Score 0.57
HY-N2387Pinosylvin -
Similarity Score 0.56
![4-[[(4-Fluorophenyl)imino]methyl]phenol-<sup>13</sup>C<sub>6</sub> Chemical Structure](//file.medchemexpress.com/product_pic/hy-w751537.gif)
HY-W7515374-[[(4-Fluorophenyl)imino]methyl]phenol-13C6 -
Similarity Score 0.56
HY-W094747(E),(E)-Benzalazine -
Similarity Score 0.56
HY-W094747ABenzalazine -
Similarity Score 0.55
HY-W009730R2,2'-((1E,1'E)-Hydrazine-1,2-diylidenebis(methanylylidene))diphenol (Standard) -
Explore the MedChemAI to find more analogs
![4-[[(4-Fluorophenyl)imino]methyl]phenol-<sup>13</sup>C<sub>6</sub> Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w751537.gif)
References
- [1]. Xi Chen, Shijun Zhong, Xiao Zhu, et al. Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair. Cancer Res 2008; 68: (9). May 1, 2008
- [2]. Devashree Jahagirdar, et al. Combinatorial Use of DNA Ligase Inhibitor L189 and Temozolomide Potentiates Cell Growth Arrest in HeLa. Current Cancer Therapy Reviews, 2018, 14, 1-11.
