1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. L189

L189 

Cat. No.: HY-15588 Purity: >98.0%
Handling Instructions

L189 is a novel human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM.

For research use only. We do not sell to patients.

L189 Chemical Structure

L189 Chemical Structure

CAS No. : 64232-83-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
50 mg USD 420 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

L189 is a novel human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM. IC50 value: 5/9/5 μM (for hLigI/III/IV) Target: DNA ligase in vitro: L189 is a competitive inhibitor with respect to nicked DNA. L189 inhibits DNA ligases I, III and IV in DNA joining assays with purified proteins and in cell extract assays of DNA replication, base excision repair and non-homologous end joinging. L189 markedly increases killing of HCT116 colon cancer cells and the other cancer cell lines by ionizing radiation.

Molecular Weight

246.29

Formula

C₁₁H₁₀N₄OS

CAS No.

64232-83-3

SMILES

OC1=NC(S)=NC(N)=C1/N=C/C2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (133.99 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0603 mL 20.3013 mL 40.6025 mL
5 mM 0.8121 mL 4.0603 mL 8.1205 mL
10 mM 0.4060 mL 2.0301 mL 4.0603 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.15 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

L189L 189L-189DNA/RNA SynthesisInhibitorinhibitorinhibit

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L189
Cat. No.:
HY-15588
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