6501-72-0
6501-72-0
Chemical Structure
VGX-1027
Synonym(s): GIT 27
- CAS No.: 6501-72-0
- Formula:C11H11NO3
- Molecular Weight:205.21
IUPAC Name: 2-(3-phenyl-4,5-dihydroisoxazol-5-yl)acetic acid
InChIKey: MUFJHYRCIHHATF-UHFFFAOYSA-N
SMILES: O=C(O)CC1CC(C2=CC=CC=C2)=NO1
Biological Activity: VGX-1027 is an orally active isoxazole compound that exhibits various immunomodulatory properties. VGX-1027 targets macrophages, reducing the production of the proinflammatory mediators TNF-α, IL-1β, IL-10. VGX-1027 has antidiabetogenic effects by limiting cytokine-mediated immunoinflammatory events[1][2][3].
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VGX-1027 | 99.67% | VGX-1027 is an orally active isoxazole compound that exhibits various immunomodulatory properties. VGX-1027 targets macrophages, reducing the production of the proinflammatory mediators TNF-α, IL-1β, IL-10. VGX-1027 has antidiabetogenic effects by limiting cytokine-mediated immunoinflammatory events. | ||||||||||||||||||||
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4-Phenylbutyric acid | 99.98% | 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. | ||||||||||||||||||||
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Harzialacton A | Harzialacton A has weak cytotoxicity to P388 leukemia cells with ED50 of > 100 μg/mL. | |||||||||||||||||||||
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3-Benzoylpropionic acid (Standard) | ≥98% | 3-Benzoylpropionic acid (Standard) is the analytical standard of 3-Benzoylpropionic acid. This product is intended for research and analytical applications. 3-Benzoylpropionic acid can be used as an intermediate in organic synthesis for the preparation of other organic compounds. | ||||||||||||||||||||
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3-Amino-3-phenylpropionic acid | 99.45% | 3-Amino-3-phenylpropionic acid (DL-β-Phenylalanine) is a structural GABA analogue. 3-Amino-3-phenylpropionic acid inhibits baclofen (HY-B0007) induced gastric acid secretion. | ||||||||||||||||||||
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Glycopyrronium impurity 5 | Glycopyrronium impurity 5 is an impurity of Glycopyrronium. | |||||||||||||||||||||
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H-β-HoPhe-OH.HCl | 99.34% | H-β-HoPhe-OH.HCl is a phenylalanine derivative. | ||||||||||||||||||||
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3-Phenylbutyric acid | 99.94% | 3-Phenylbutyric acid is metabolized by initial oxidation of the benzene ring and by initial oxidation of the side chain. 3-Phenylbutyric acid can be used to isolate Rhodococcus rhodochrous PB1 from compost soil. | ||||||||||||||||||||
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Phenibut hydrochloride | 98.0% | Phenibut (β-Phenyl-GABA) hydrochloride is an orally active GABA-B agonist. Phenibut hydrochloride acts as a GABA-mimetic, primarily at GABAB?receptors. Phenibut hydrochloride has anxiolytic and nootropic (cognition enhancing) effects. | ||||||||||||||||||||
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Hydrocinnamic acid | 99.95% | Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activities. | ||||||||||||||||||||
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Hydrocinnamic acid-2,3-13C2 | Hydrocinnamic acid-2,3-13C2 is the 13C-labeled Hydrocinnamic acid. Hydrocinnamic acid is the major rhizospheric compound with known growth regulatory activities. | |||||||||||||||||||||
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References
- [1]. Stosic-Grujicic S, et al. A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice. J Pharmacol Exp Ther. 2007 Mar;320(3):1038-49. [Content Brief]
- [2]. Danijela Maksimovic-Ivanic, et al. Anticancer properties of the novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo. Mol Cancer Ther. 2008 Mar;7(3):510-20. [Content Brief]
- [3]. K Mangano, et al. Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats. Br J Pharmacol. 2008 Nov;155(5):722-30. [Content Brief]
