6501-72-0
6501-72-0
Chemical Structure
VGX-1027
Synonym(s): GIT 27
- CAS No.: 6501-72-0
- Formula:C11H11NO3
- Molecular Weight:205.21
IUPAC Name: 2-(3-phenyl-4,5-dihydroisoxazol-5-yl)acetic acid
InChIKey: MUFJHYRCIHHATF-UHFFFAOYSA-N
SMILES: O=C(O)CC1CC(C2=CC=CC=C2)=NO1
Biological Activity: VGX-1027 is an orally active isoxazole compound that exhibits various immunomodulatory properties. VGX-1027 targets macrophages, reducing the production of the proinflammatory mediators TNF-α, IL-1β, IL-10. VGX-1027 has antidiabetogenic effects by limiting cytokine-mediated immunoinflammatory events[1][2][3].
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VGX-1027 | 99.67% | VGX-1027 is an orally active isoxazole compound that exhibits various immunomodulatory properties. VGX-1027 targets macrophages, reducing the production of the proinflammatory mediators TNF-α, IL-1β, IL-10. VGX-1027 has antidiabetogenic effects by limiting cytokine-mediated immunoinflammatory events. | ||||||||||||||||||||
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References
- [1]. Stosic-Grujicic S, et al. A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice. J Pharmacol Exp Ther. 2007 Mar;320(3):1038-49. [Content Brief]
- [2]. Danijela Maksimovic-Ivanic, et al. Anticancer properties of the novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo. Mol Cancer Ther. 2008 Mar;7(3):510-20. [Content Brief]
- [3]. K Mangano, et al. Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats. Br J Pharmacol. 2008 Nov;155(5):722-30. [Content Brief]
Keywords
