652-67-5
652-67-5
Chemical Structure
Isosorbide
Synonym(s): D-Isosorbide; Dianhydro-D-glucitol
- CAS No.: 652-67-5
- Formula:C6H10O4
- Molecular Weight:146.14
IUPAC Name: (3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diol
InChIKey: KLDXJTOLSGUMSJ-JGWLITMVSA-N
SMILES: O[C@H]1[C@]2([H])[C@]([C@@H](O)CO2)([H])OC1
Biological Activity: Isosorbide (D-Isosorbide), an orally active vasodilating agent that can be used for the research of heart failure and angina (chest pain). Isosorbide is also an oral hyperosmotic diuretic[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Isosorbide | 98.76% | Isosorbide (D-Isosorbide), an orally active vasodilating agent that can be used for the research of heart failure and angina (chest pain). Isosorbide is also an oral hyperosmotic diuretic. | ||||||||||||||||||||
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Isosorbide (Standard) | ≥98% | Isosorbide (Standard) is the analytical standard of Isosorbide. This product is intended for research and analytical applications. Isosorbide (D-Isosorbide), an orally active vasodilating agent that can be used for the research of heart failure and angina (chest pain). Isosorbide is also an oral hyperosmotic diuretic. | ||||||||||||||||||||
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Isosorbide-d8 | Isosorbide-d8 is the deuterium labeled Isosorbide (HY-B1469). Isosorbide (D-Isosorbide), an orally active vasodilating agent that can be used for the research of heart failure and angina (chest pain). Isosorbide is also an oral hyperosmotic diuretic. | |||||||||||||||||||||
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D-Xylopyranose | D-Xylopyranose is a type of sugar. D-Xylopyranose exists in the forms of α-D-Xylopyranose (HY-N2018) and β-D-Xylopyranose. β-D-Xylopyranose is regarded as a model structural motif of the fundamental chemical structure of hemicellulose. | |||||||||||||||||||||
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Isosorbide dimethyl ether | 99.64% | Isosorbide dimethyl ether (Dimethyl isosorbide) is a bio-based green solvent. Isosorbide dimethyl ether is used for the preparation of sustainable ultrafiltration and microfiltration membranes. Isosorbide dimethyl ether can serve as an eco-friendly eluent for liquid chromatography. When used as a liquid chromatography mobile phase at a ratio of 50% (v/v) under 40 °C, with a system back pressure of 160-300 bar and an ultraviolet cutoff wavelength of 240 nm, Isosorbide dimethyl ether enables the quantitative analysis of Methylparaben (HY-W016806) and Propylparaben (HY-N2026) in biological preparations. | ||||||||||||||||||||
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α-D-Xylose | 99.90% | α-D-Xylose (α-D-Xylopyranose) is a basic component of the five-carbon fraction of biomass and a precursor of hemicellulose. α-D-Xylose participates in a variety of enzyme-catalyzed reactions, which in turn participate in a variety of metabolic pathways. In addition, α-D-Xylose is also used in tanning, dyeing and as a diabetic food. | ||||||||||||||||||||
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D-Arabinopyranose (Standard) | 99.78% | D-Arabinopyranose (Standard) is the analytical standard of D-Arabinopyranose (HY-N7082). This product is intended for research and analytical applications. D-Arabinpyranose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinpyranose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinpyranose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinpyranose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinpyranose is the ring-opened form of the aldopentose D-Arabinpyranose (HY-N7082). | ||||||||||||||||||||
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1,5-Anhydro-D-mannitol | 1,5-Anhydro-D-mannitol is the analogue of 1,5-Anhydrosorbitol (HY-113075), and can be used as an experimental control. 1,5-Anhydrosorbitol is a short-term marker for glycemic control. | |||||||||||||||||||||
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1,4-Anhydro-D-xylitol | 1,4-Anhydro-D-xylitol is a compound belonging to the class of sugar alcohols. It is derived from xylitol, a natural sweetener found in many fruits and vegetables. 1,4-Anhydro-D-xylitol is commonly used as a low-calorie sweetener and excipient in the food and pharmaceutical industries, and as a filler or binder in pharmaceutical formulations. It has also been investigated for its potential use in the development of biodegradable plastics and other sustainable materials. | |||||||||||||||||||||
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(3R,4S,5S)-Tetrahydro-2H-pyran-2,3,4,5-tetraol (Standard) | ≥98% | (3R,4S,5S)-Tetrahydro-2H-pyran-2,3,4,5-tetraol (Standard) is the analytical standard of (3R,4S,5S)-Tetrahydro-2H-pyran-2,3,4,5-tetraol. This product is intended for research and analytical applications. L-Arabinopyranose is an endogenous metabolite present in Urine that can be used for the research of Ribose 5 Phosphate Isomerase Deficiency. | ||||||||||||||||||||
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Isomannide | 99.44% | Isomannide (1,4:3,6-Dianhydromannitol) is a cyclic diol and a derivative of Isosorbide (HY-B1469). Isomannide serves as a starting material for chiral solubilizers and a linker group for novel bacterial topoisomerase inhibitors (NBTIs). Isomannide is also used in the synthesis of biocompatible polymers. | ||||||||||||||||||||
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1,5-Anhydrosorbitol-13C6 | 1,5-Anhydrosorbitol-13C6 (1,5-Anhydro-D-glucitol-13C6) is the 13C-labeled 1,5-Anhydrosorbitol (HY-113075). 1,5-Anhydrosorbitol is a short-term marker for glycemic control. | |||||||||||||||||||||
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References
- [1]. Rose M, et, al. Isosorbide as a renewable platform chemical for versatile applications--quo vadis? ChemSusChem. 2012 Jan 9;5(1):167-76. [Content Brief]
- [2]. Nozawa I, et, al. Efficacy of long-term administration of isosorbide for Ménière's disease. ORL J Otorhinolaryngol Relat Spec. May-Jun 1995;57(3):135-40. [Content Brief]
