67-16-3
67-16-3
Chemical Structure
Thiamine disulfide
- CAS No.: 67-16-3
- Formula:C24H34N8O4S2
- Molecular Weight:562.71
IUPAC Name: N,N'-((2E,2'E)-disulfanediylbis(5-hydroxypent-2-ene-3,2-diyl))bis(N-((4-amino-2-methylpyrimidin-5-yl)methyl)formamide)
InChIKey: GFEGEDUIIYDMOX-YHARCJFQSA-N
SMILES: C/C(N(CC1=CN=C(C)N=C1N)C=O)=C(SS/C(CCO)=C(N(CC2=CN=C(C)N=C2N)C=O)\C)/CCO
Biological Activity: Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Thiamine disulfide | 99.54% | Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity. | ||||||||||||||||||||
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Thiamine disulfide (Standard) | 99.22% | Thiamine disulfide (Standard) is the analytical standard of Thiamine disulfide. This product is intended for research and analytical applications. Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity. | ||||||||||||||||||||
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Octotiamine | Octotiamine (TATD) is a vitamin B1 analogue, a component of vitamin complex. Octotiamine can be used for the research of vitamin B1 deficiency. | |||||||||||||||||||||
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Prosultiamine | Prosultiamine is an allithiamine homolog. Prosultiamine can disrupt intracellular redox reactions, inducing caspase-dependent apoptosis in HTLV-1 infected cells. Prosultiamine can be used in studies involving lower urinary tract dysfunction associated with human T-lymphotropic virus type 1-related myelopathy/tropical spastic paraparesis. |
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Bisbentiamine | 99.52% | Bisbentiamine is a lipophilic thiamine prodrug with pH-dependent solubility. The bioavailability of Bisbentiamine is regulated by diet type, administration time, gastric acidity, and formulation. | ||||||||||||||||||||
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Acefurtiamine | Acefurtiamine is a vitamin B1 analogue. | |||||||||||||||||||||
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Benfotiamine (Standard) | ≥98% | Benfotiamine (Standard) is the analytical standard of Benfotiamine. This product is intended for research and analytical applications. Benfotiamine (S-Benzoylthiamine O-monophosphate) is a vitamin B1 derivative that exhihibits potent antioxidative and anti-inflammatory activity. Benfotiamine can be used for the research of various secondary diabetic complications. Benfotiamine also can be used in infectious diseases such as HIV and COVID-19. | ||||||||||||||||||||
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Fursultiamine (Standard) | ≥98% | Fursultiamine (Standard) is the analytical standard of Fursultiamine. This product is intended for research and analytical applications. Fursultiamine is a vitamin B1 derivative, has anti-nociceptive and antineoplastic activity. Fursultiamine can be used for vitamin B1 deficiency, osteoarthritis (OA) and cancer research. | ||||||||||||||||||||
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Thiamine disulfide dinitrate | Thiamine Disulfide Nitrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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Sulbutiamine (Standard) | ≥98% | Sulbutiamine (Standard) is the analytical standard of Sulbutiamine. This product is intended for research and analytical applications. Sulbutiamine is a synthetic analogue of vitamin B1 used for the treatment of asthenia. | ||||||||||||||||||||
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Sulbutiamine-d14 | Sulbutiamine-d14 is deuterated labeled Sulbutiamine. | |||||||||||||||||||||
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Allithiamine | 96.78% | Allithiamine is a thiamin derivative with absorption characteristics similar to fat-soluble vitamins. Allithiamine acts as a cofactor precursor for thiamin pyrophosphate (TPP), which participates in carbohydrate metabolism by supporting the pyruvate dehydrogenase (PDH) complex to facilitate pyruvate entry into the tricarboxylic acid (TCA) cycle as acetyl CoA. Allithiamine can be used for researching thiamin metabolism. | ||||||||||||||||||||
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References
- [1]. S Shoji, et al. Thiamine disulfide as a potent inhibitor of human immunodeficiency virus (type-1) production. Biochem Biophys Res Commun. 1994 Nov 30;205(1):967-75. [Content Brief]
- [2]. Y Komata, et al. In vitro percutaneous absorption of thiamine disulfide from a mixture of propylene glycol and fatty acid. J Pharm Sci. 1992 Aug;81(8):744-6. [Content Brief]
