7226-77-9
7226-77-9
Chemical Structure
5-Hydroxymethyl-2’-deoxycytidine
Synonym(s): 5hmdC
- CAS 番号: 7226-77-9
- Formula:C10H15N3O5
- Molecular Weight:257.24
IUPAC Name: 4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(hydroxymethyl)pyrimidin-2(1H)-one
InChIKey: HMUOMFLFUUHUPE-XLPZGREQSA-N
SMILES: O[C@H]1C[C@H](N2C(N=C(N)C(CO)=C2)=O)O[C@@H]1CO
Biological Activity: 5-Hydroxymethyl-2’-deoxycytidine (5hmdC) is an oxidation derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2’-deoxycytidine may serve as a marker of irreversibly damaged cells[1][2].
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5-Hydroxymethyl-2’-deoxycytidine | 99.96% | 5-Hydroxymethyl-2’-deoxycytidine (5hmdC) is an oxidation derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2’-deoxycytidine may serve as a marker of irreversibly damaged cells. | ||||||||||||||||||||
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5-Hydroxymethyl-2'-deoxycytidine-d3 | 99.90% | 5-Hydroxymethyl-2'-deoxycytidine-d3 (5hmdC-d3) is the deuterium labeled 5-Hydroxymethyl-2'-deoxycytidine (HY-131394). 5-Hydroxymethyl-2’-deoxycytidine (5hmdC) is an oxidation derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2’-deoxycytidine may serve as a marker of irreversibly damaged cells. | ||||||||||||||||||||
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References
- [1]. Ewelina Zarakowska, et al. Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1003-1009. [Content Brief]
- [2]. Shuo Liu, et al. Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA. Nucleic Acids Res. 2013 Jul;41(13):6421-9. [Content Brief]
