5-Hydroxymethyl-2'-deoxycytidine-d3
Based on 1 Customer Validation
5-Hydroxymethyl-2'-deoxycytidine-d3 (5hmdC-d3) is the deuterium labeled 5-Hydroxymethyl-2'-deoxycytidine (HY-131394). 5-Hydroxymethyl-2’-deoxycytidine (5hmdC) is an oxidation derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2’-deoxycytidine may serve as a marker of irreversibly damaged cells.
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- Reinheit : 99.90%
- CAS. Nr.: 1585142-60-4
- Formel: C10H12D3N3O5
- Molecular Weight:260.26
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1585142-60-4
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Unlabeled CAS 7226-77-9
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Appearance Solid
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Molecular Weight 260.26
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Formel C10H12D3N3O5
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Color White to off-white
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SMILES
OC[C@@H]1[C@@H](O)C[C@H](N2C(N=C(N)C(C([2H])([2H])O)=C2[2H])=O)O1
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Synonyms
5hmdC-d3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (192.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Ewelina Zarakowska, et al. Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1003-1009. [Content Brief]
[2]. Shuo Liu, et al. Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA. Nucleic Acids Res. 2013 Jul;41(13):6421-9. [Content Brief]
[3]. Tang Y, et al., Sensitive and simultaneous determination of 5-methylcytosine and its oxidation products in genomic DNA by chemical derivatization coupled with liquid chromatography-tandem mass spectrometry analysis. Anal Chem. 2015 Mar 17;87(6):3445-52. [Content Brief]
[4]. Zhang HY, et al., The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals. Chem Commun (Camb). 2016 Jan 14;52(4):737-40. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8423 mL | 19.2116 mL | 38.4231 mL | 96.0578 mL |
| 5 mM | 0.7685 mL | 3.8423 mL | 7.6846 mL | 19.2116 mL | |
| 10 mM | 0.3842 mL | 1.9212 mL | 3.8423 mL | 9.6058 mL | |
| 15 mM | 0.2562 mL | 1.2808 mL | 2.5615 mL | 6.4039 mL | |
| 20 mM | 0.1921 mL | 0.9606 mL | 1.9212 mL | 4.8029 mL | |
| 25 mM | 0.1537 mL | 0.7685 mL | 1.5369 mL | 3.8423 mL | |
| 30 mM | 0.1281 mL | 0.6404 mL | 1.2808 mL | 3.2019 mL | |
| 40 mM | 0.0961 mL | 0.4803 mL | 0.9606 mL | 2.4014 mL | |
| 50 mM | 0.0768 mL | 0.3842 mL | 0.7685 mL | 1.9212 mL | |
| 60 mM | 0.0640 mL | 0.3202 mL | 0.6404 mL | 1.6010 mL | |
| 80 mM | 0.0480 mL | 0.2401 mL | 0.4803 mL | 1.2007 mL | |
| 100 mM | 0.0384 mL | 0.1921 mL | 0.3842 mL | 0.9606 mL |
5-Hydroxymethyl-2'-deoxycytidine-d3 Related Classifications
HY-W654228 Related Classifications
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