79902-63-9
79902-63-9
Chemical Structure
Simvastatin
Synonym(s): MK 733
- CAS No.: 79902-63-9
- Formula:C25H38O5
- Molecular Weight:418.57
IUPAC Name: (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
InChIKey: RYMZZMVNJRMUDD-HGQWONQESA-N
SMILES: CCC(C)(C)C(O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(O3)=O)[C@@]12[H])=O
Biological Activity: Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
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Simvastatin | 99.56% | Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. | ||||||||||||||||||||
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Simvastatin (Standard) | 98.97% | Simvastatin (Standard) is the analytical standard of Simvastatin. This product is intended for research and analytical applications. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. | ||||||||||||||||||||
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Simvastatin-d11 | Simvastatin-d11 is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. | |||||||||||||||||||||
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Simvastatin-d6 | 99.6% | Simvastatin-d6 (MK 733-d6) is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. | ||||||||||||||||||||
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Simvastatin-d3 | 98.61% | Simvastatin-d3 is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. | ||||||||||||||||||||
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2'-Ethyl Simvastatin | 2'-Ethyl Simvastatin (compound 6) is a Mevinolin analog, with HMG-CoA reductase inhibition. | |||||||||||||||||||||
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Simvastatin impurity 11 | Simvastatin impurity 11 is an impurity of Simvastatin. | |||||||||||||||||||||
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4-Acetylsimvastatin | 4-Acetylsimvastatin is an acetylated simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. | |||||||||||||||||||||
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(Rac)-3′-Hydroxy simvastatin | (Rac)-3′-Hydroxy simvastatin is an isomer of 3′-Hydroxy simvastatin. 3′-Hydroxy simvastatin is an oxidative metabolite of Simvastatin (HY-17502) produced by hepatic CYP450 metabolism, and is also the major terminal metabolite of Simvastatin in rats. 3′-Hydroxy simvastatin possesses HMG-CoA Reductase inhibitory activity. 3′-Hydroxy simvastatin is used in metabolism-related research. | |||||||||||||||||||||
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3'-Hydroxy simvastatin | 99.71% | 3′-Hydroxy simvastatin is an oxidative metabolite of Simvastatin (HY-17502) produced by hepatic CYP450 metabolism, and is also the major terminal metabolite of Simvastatin in rats. 3′-Hydroxy simvastatin possesses HMG-CoA Reductase inhibitory activity. 3′-Hydroxy simvastatin is used in metabolism-related research. | ||||||||||||||||||||
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Lovastatin | 99.75% | Lovastatin (Mevinolin) is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol. | ||||||||||||||||||||
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Simvastatin impurity 14 | Simvastatin impurity 14 is an impurity of Simvastatin. | |||||||||||||||||||||
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Simvastatin impurity 12 | Simvastatin impurity 12 is an impurity of Simvastatin. | |||||||||||||||||||||
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Simvastatin impurity 3 | Simvastatin impurity 3 is an impurity of Simvastatin. | |||||||||||||||||||||
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