829-74-3
829-74-3
Chemical Structure
Levonordefrin
Synonym(s): (-)-Cobefrin;(-)-α-Methylnoradrenaline;(-)-Nordefrin
- CAS No.: 829-74-3
- Formula:C9H13NO3
- Molecular Weight:183.21
IUPAC Name: 4-((1R,2S)-2-amino-1-hydroxypropyl)benzene-1,2-diol
InChIKey: GEFQWZLICWMTKF-CDUCUWFYSA-N
SMILES: OC1=CC=C([C@@H](O)[C@@H](N)C)C=C1O
Biological Activity:
Levonordefrin ((-)-Cobefrin; (-)-α-Methylnoradrenaline; (-)-Nordefrin) is an α-adrenergic receptor agonist with blood pressure regulatory properties. Levonordefrin is a key metabolite responsible for the hypotensive effect of α-methyldopa. By stimulating central α-adrenergic receptors in the nucleus tractus solitarius region of the medulla oblongata, Levonordefrin induces centrally mediated hypotension and bradycardia. When administered intravenously, Levonordefrin increases mean arterial blood pressure in a dose-dependent manner. Levonordefrin is applicable for research on the pathophysiology of hypertension and drug metabolism[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Levonordefrin | 98.38% | Levonordefrin ((-)-Cobefrin; (-)-α-Methylnoradrenaline; (-)-Nordefrin) is an α-adrenergic receptor agonist with blood pressure regulatory properties. Levonordefrin is a key metabolite responsible for the hypotensive effect of α-methyldopa. By stimulating central α-adrenergic receptors in the nucleus tractus solitarius region of the medulla oblongata, Levonordefrin induces centrally mediated hypotension and bradycardia. When administered intravenously, Levonordefrin increases mean arterial blood pressure in a dose-dependent manner. Levonordefrin is applicable for research on the pathophysiology of hypertension and drug metabolism. |
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Levonordefrin (Standard) | ≥98% | Levonordefrin (Standard) is the analytical standard of Levonordefrin. This product is intended for research and analytical applications. Levonordefrin ((-)-Cobefrin; (-)-α-Methylnoradrenaline; (-)-Nordefrin) is an α-adrenergic receptor agonist with blood pressure regulatory properties. Levonordefrin is a key metabolite responsible for the hypotensive effect of α-methyldopa. By stimulating central α-adrenergic receptors in the nucleus tractus solitarius region of the medulla oblongata, Levonordefrin induces centrally mediated hypotension and bradycardia. When administered intravenously, Levonordefrin increases mean arterial blood pressure in a dose-dependent manner. Levonordefrin is applicable for research on the pathophysiology of hypertension and drug metabolism. | ||||||||||||||||||||
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Droxidopa (Standard) | ≥98% | Droxidopa (Standard) is the analytical standard of Droxidopa. This product is intended for research and analytical applications. Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder). | ||||||||||||||||||||
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Droxidopa-13C6 | Droxidopa-13C6 (L-DOPS-13C6) is 13C labeled Droxidopa. Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder). | |||||||||||||||||||||
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Norepinephrine (Standard) | 99.97% | Norepinephrine (Standard) is the analytical standard of Norepinephrine. This product is intended for research and analytical applications. Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors. | ||||||||||||||||||||
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rac-Levonordefrin | Rac-Levonordefrin (rac-Cobefrin; rac-α-Methylnoradrenaline; rac-Nordefrin) is the racemic form of Levonordefrin (HY-107915). Levonordefrin is an α-adrenergic receptor agonist with blood pressure regulating properties. | |||||||||||||||||||||
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Ethylnorepinephrine hydrochloride | Ethylnorepinephrine hydrochloride is a sympathomimetic and bronchodilator related to norepinephrine. | |||||||||||||||||||||
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Metaraminol | Metaraminol ((-)-Metaraminol) is a sympathomimetic compound with activity that acts primarily at alpha-1 adrenergic receptors. Metaraminol is used to inhibit hypotension due to vasodilation, particularly in critically ill patients who do not respond well to volume resuscitation. Metaraminol may also be used as an adjunct to help improve cardiac contractility. The use of metaraminol may be supported by less evidence, but its effectiveness in specific situations remains of interest. | |||||||||||||||||||||
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Nordefrin | Nordefrin ((±)-Cobefri), a Norepinephrine (HY-13715) derivative, is a vasoconstrictor agent. | |||||||||||||||||||||
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β,3-Dihydroxytyrosine | β,3-Dihydroxytyrosine is an amino acid derivative. | |||||||||||||||||||||
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3,4-Dihydroxyamphetamine hydrochloride | 3,4-Dihydroxyamphetamine (α-Methyldopamine) (hydrochloride) is a secondary metabolite of 3,4-Methylenedioxymethamphetamine (MDMA). 3, 4-dihydroxyamphetamine (hydrochloride) is cytotoxic to rat hepatocytes. 3, 4-dihydroxyamphetamine (hydrochloride) is also used in the study of high blood pressure. | |||||||||||||||||||||
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L-threo-Droxidopa-13C2 | L-threo-Droxidopa-13C2,15N is 13C- and 15N-labeled L-threo-Droxidopa. | |||||||||||||||||||||
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