84783-01-7
84783-01-7
Chemical Structure
K-Ras-IN-1
- CAS No.: 84783-01-7
- Formula:C11H13NOS
- Molecular Weight:207.29
IUPAC Name: (2-hydroxyphenyl)(pyrrolidin-1-yl)methanethione
InChIKey: QIKLOVZAPGSYNO-UHFFFAOYSA-N
SMILES: S=C(C1=CC=CC=C1O)N2CCCC2
Biological Activity: K-Ras-IN-1 is the inhibitor for K-Ras by occupying the binding site of son of sevenless (Sos), preventing the interaction between Sos and K-Ras, inhibiting the Sos-catalyzed GDP to GTP exchange process. K-Ras-IN-1 is promising for research of pancreatic, colon and lung cancer[1][2].
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K-Ras-IN-1 | 98.00% | K-Ras-IN-1 is the inhibitor for K-Ras by occupying the binding site of son of sevenless (Sos), preventing the interaction between Sos and K-Ras, inhibiting the Sos-catalyzed GDP to GTP exchange process. K-Ras-IN-1 is promising for research of pancreatic, colon and lung cancer. | ||||||||||||||||||||
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References
- [1]. Hocker HJ, et al. LIBSA--a method for the determination of ligand-binding preference to allosteric sites on receptor ensembles. J Chem Inf Model. 2014 Feb 24;54(2):530-538. [Content Brief]
- [2]. Sun Q, et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-3. [Content Brief]
Keywords
