Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation

  • Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-3. doi: 10.1002/anie.201201358.
Qi Sun  1 ,  Jason P Burke ,  Jason Phan ,  Michael C Burns ,  Edward T Olejniczak ,  Alex G Waterson ,  Taekyu Lee ,  Olivia W Rossanese ,  Stephen W Fesik
Affiliations
  • 1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
PMID: 22566140 DOI: 10.1002/anie.201201358
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-18674
    K-Ras-IN-1
    98.00%, K-Ras Inhibitor
    target: Ras
    Research Areas: Cancer