85-66-5
85-66-5
Chemical Structure
Pyocyanin
Synonym(s): Pyocyanine; Sanazin; Sanasin
- No. CAS: 85-66-5
- Formula:C13H10N2O
- Molecular Weight:210.23
IUPAC Name: 5-methylphenazin-1(5H)-one
InChIKey: YNCMLFHHXWETLD-UHFFFAOYSA-N
SMILES: O=C1C=CC=C2N(C3=C(C=CC=C3)N=C21)C
Biological Activity: Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity[1][2][3][4].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Pyocyanin | 99.23% | Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity. | ||||||||||||||||||||
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Pyocyanin (Standard) | ≥98% | Pyocyanin (Standard) is the analytical standard of Pyocyanin. This product is intended for research and analytical applications. Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity. | ||||||||||||||||||||
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Fc 11a-2 | 99.75% | Fc 11a-2, a benzimidazole compound, is an orally active and potent NLRP3 inflammasome inhibitor. Fc 11a-2 restrains the formation of NLRP3 inflammasome by inhibiting activation of caspase-1 and thus the activation of IL-1b/IL-18. Fc 11a-2 prevents the development of Dextran sulfate sodium (DSS; HY-116282C)-induced murine experimental colitis. | ||||||||||||||||||||
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2-Methyl-3-phenylquinoxaline | 98.70% | 2-Methyl-3-phenylquinoxaline (compound 38) is a potent platelet-derived growth factor receptor tyrosine kinase (PDGF-RTK) inhibitor with modest inhibitory activity against PDGFR kinase in intact cells (IC50 greater than 100 μM). | ||||||||||||||||||||
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2-(3-Chlorophenyl)-1H-benzo[d]imidazole | 2-(3-Chlorophenyl)-1H-benzo[d]imidazole is an antibacterial agent. 2-(3-Chlorophenyl)-1H-benzo[d]imidazole can be used in the research of bacterial infections and fungal infections. | |||||||||||||||||||||
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Alloxazine | 99.46% | Alloxazine is a selective A2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer. | ||||||||||||||||||||
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Lavanducyanin | Lavanducyanin (WS-9659 A) is an antibiotic targeting microbial cell membranes. Lavanducyanin is promising for research of infections and cancer adjuvants. | |||||||||||||||||||||
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1-Hydroxy-N-methylacridone | 1-Hydroxy-N-methylacridone is an acridone alkaloid from Boronia lanceolate. | |||||||||||||||||||||
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Chlorfenazole | 99.85% | Chlorfenazole (o-Chlorobenzimidazole) is a benzimidazole-based compound. Chlorfenazole is used in the research of intestinal nematode diseases. | ||||||||||||||||||||
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2-(2′-Hydroxyphenyl)benzimidazole | 99.92% | 2-(2′-Hydroxyphenyl) benzimidazole is the most extensively studied excited-state intramolecular proton transfer (ESIPT) molecule, exhibiting normal and tautomer emissions. 2-(2′-Hydroxyphenyl) benzimidazole has been applied as a fluorescent probe in various systems. | ||||||||||||||||||||
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1-Hydroxyacridin-9(10H)-one | 1-Hydroxyacridin-9 (10H)-one (Compound 2a) is an Acridone (HY-W007771) derivative. 1-Hydroxyacridin-9 (10H)-one does not inhibit ABCG2-mediated efflux of Mitoxantrone (HY-13502), with an IC50 > 20 μM. | |||||||||||||||||||||
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Eduleine | Eduleine is an alkaloid found in Lunasia quercifolia in the Australian Rutaceae family. Eduleine is promising for research of antioxidants and enzyme inhibitors. | |||||||||||||||||||||
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References
- [1]. Paulina Castañeda-Tamez, et al. Pyocyanin Restricts Social Cheating in Pseudomonas aeruginosa. Front Microbiol. 2018 Jun 27;9:1348. [Content Brief]
- [2]. Marreiro de Sales-Neto J, et al. Anti-inflammatory potential of pyocyanin in LPS-stimulated murine macrophages. Immunopharmacol Immunotoxicol. 2019 Feb;41(1):102-108. [Content Brief]
- [3]. Kamer AMA, et al. Antibacterial, antibiofilm, and anti-quorum sensing activities of pyocyanin against methicillin-resistant Staphylococcus aureus: in vitro and in vivo study. BMC Microbiol. 2023 Apr 24;23(1):116. [Content Brief]
- [4]. Arora D, et al. Pyocyanin induces systemic oxidative stress, inflammation and behavioral changes in vivo. Toxicol Mech Methods. 2018 Jul;28(6):410-414. [Content Brief]
