86009-41-8
Chemical Structure
PDE1-IN-11
- CAS No.: 86009-41-8
- Formula:C14H18N2OS
- Molecular Weight:262.37
InChIKey: UJLNRIYQKYEMIB-UHFFFAOYSA-N
SMILES: O=C1C2=C(SC3=C2CCCC3)N=CN1CCCC
Biological Activity: PDE1-IN-11 (Compound 5cc) is an orally active and highly selective PDE1A1 inhibitor. PDE1-IN-11 increases intracellular cAMP and cGMP levels, activating the PKA-CREB and NO-cGMP-PKG signaling pathways, promoting osteoblast differentiation and bone formation, while suppressing osteoclastogenesis and bone resorption. PDE1-IN-11 is promising for research of postmenopausal osteoporosis (PMO) and other bone metabolism disorders[1].
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PDE1-IN-11 | 99.24% | PDE1-IN-11 (Compound 5cc) is an orally active and highly selective PDE1A1 inhibitor. PDE1-IN-11 increases intracellular cAMP and cGMP levels, activating the PKA-CREB and NO-cGMP-PKG signaling pathways, promoting osteoblast differentiation and bone formation, while suppressing osteoclastogenesis and bone resorption. PDE1-IN-11 is promising for research of postmenopausal osteoporosis (PMO) and other bone metabolism disorders. | ||||||||||||||||||||
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Keywords
