PDE1-IN-11
Based on 1 Customer Validation
PDE1-IN-11 (Compound 5cc) is an orally active and highly selective PDE1A1 inhibitor. PDE1-IN-11 increases intracellular cAMP and cGMP levels, activating the PKA-CREB and NO-cGMP-PKG signaling pathways, promoting osteoblast differentiation and bone formation, while suppressing osteoclastogenesis and bone resorption. PDE1-IN-11 is promising for research of postmenopausal osteoporosis (PMO) and other bone metabolism disorders.
For research use only. We do not sell to patients.
- Purity: 99.24%
- CAS No.: 86009-41-8
- Formula: C14H18N2OS
- Molecular Weight:262.37
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
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Metabolism/Protease Compound Library
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Neurodegenerative Disease-related Compound Library
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Transcription Factor-Targeted Library
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Anti-Colorectal Cancer Compound Library
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Anti-Prostate Cancer Compound Library
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Osteogenesis Compound Library
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Pain-Related Compound Library
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Metabolic Enzyme Compound Library
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Highly Selective Inhibitors Library
HY-L158
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MCE Bioactive Compound Library
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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PDE1A |
Chemical Information
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CAS No. 86009-41-8
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Appearance Solid
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Molecular Weight 262.37
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Formula C14H18N2OS
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Color Light yellow to yellow
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SMILES
O=C1C2=C(SC3=C2CCCC3)N=CN1CCCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 10 mg/mL (38.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.8114 mL | 19.0571 mL | 38.1141 mL | 95.2853 mL |
| 5 mM | 0.7623 mL | 3.8114 mL | 7.6228 mL | 19.0571 mL | |
| 10 mM | 0.3811 mL | 1.9057 mL | 3.8114 mL | 9.5285 mL | |
| 15 mM | 0.2541 mL | 1.2705 mL | 2.5409 mL | 6.3524 mL | |
| 20 mM | 0.1906 mL | 0.9529 mL | 1.9057 mL | 4.7643 mL | |
| 25 mM | 0.1525 mL | 0.7623 mL | 1.5246 mL | 3.8114 mL | |
| 30 mM | 0.1270 mL | 0.6352 mL | 1.2705 mL | 3.1762 mL |
PDE1-IN-11 Related Classifications
HY-178478 Related Classifications
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