92-78-4
92-78-4
Chemical Structure
Naphthol AS-E
- CAS No.: 92-78-4
- Formula:C17H12ClNO2
- Molecular Weight:297.74
IUPAC Name: N-(4-chlorophenyl)-3-hydroxy-2-naphthamide
InChIKey: OHAXNCGNVGGWSO-UHFFFAOYSA-N
SMILES: O=C(C1=C(O)C=C2C=CC=CC2=C1)NC3=CC=C(Cl)C=C3
Biological Activity: Naphthol AS-E is a potent and cell-permeable inhibitor of KIX-KID interaction. Naphthol AS-E directly binds to the KIX domain of CBP (Kd:8.6 μM), blocks the interaction between the KIX domain and the KID domain of CREB with IC50 of 2.26 μM. Naphthol AS-E can be used for cancer research.
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Naphthol AS-E | 98.0% | Naphthol AS-E is a potent and cell-permeable inhibitor of KIX-KID interaction. Naphthol AS-E directly binds to the KIX domain of CBP (Kd:8.6 μM), blocks the interaction between the KIX domain and the KID domain of CREB with IC50 of 2.26 μM. Naphthol AS-E can be used for cancer research. | ||||||||||||||||||||
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Naphthol AS-E (Standard) | ≥98% | Naphthol AS-E (Standard) is the analytical standard of Naphthol AS-E (HY-104068). This product is intended for research and analytical applications. Naphthol AS-E is a potent and cell-permeable inhibitor of KIX-KID interaction. Naphthol AS-E directly binds to the KIX domain of CBP (Kd:8.6 μM), blocks the interaction between the KIX domain and the KID domain of CREB with IC50 of 2.26 μM. Naphthol AS-E can be used for cancer research. | ||||||||||||||||||||
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KG-501 (Standard) | ≥98% | KG-501 (Standard) is the analytical standard of KG-501 (HY-103299). This product is intended for research and analytical applications. KG-501 is a CREB inhibitor, with an IC50 of 6.89 μM. | ||||||||||||||||||||
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Naphthol AS-OL | 99.05% | Naphthol AS-OL (C.I. 37530) is a glucuronide taht can be used as a substrate of β-glucuronidase. Naphthol AS-OL can be used to detect β-glucuronidase activity. | ||||||||||||||||||||
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CP-74006 | 98.86% | CP-74006 (compound11h) is a selective Cyclooxygenase-1 inhibitor. | ||||||||||||||||||||
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XX-650-23 | 99.90% | XX-650-23 is a potent CREB inhibitor. XX-650-23inhibits CREB function through disruption of CBP-CREB interaction. XX-650-23 can be used for AML research. | ||||||||||||||||||||
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KLK6-IN-1 | KLK6-IN-1 is a reversible small‑molecule inhibitor of KLK6, KLK1, and plasmin. KLK6-IN-1 shows IC50 values of 1.57 μM (KLK6), 5.1 μM (KLK1), 7.4 μM (plasmin), and Ki values of 0.8 μM (KLK6), 2.4 μM (KLK1), 1.3 μM (plasmin). KLK6-IN-1 is highly selective for KLK6 and its proteolytic network. KLK6-IN-1 induces oligodendrocyte differentiation by promoting oligodendrocyte precursor cell maturation. KLK6-IN-1 can be used for the research of multiple sclerosis. | |||||||||||||||||||||
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Osalmid | 99.91% | Osalmid is a ribonucleotide reductase small subunit M2 (RRM2) targeting compound; suppresses ribonucleotide reductase activity with an IC50 of 8.23 μM. | ||||||||||||||||||||
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Multifungin | 99.19% | Multifungin (Bromochlorosalicylanilide) is an antifungal that treats oral candidiasis. Multifungin prevents the formation and accumulation of Zearalenone and reduces the fungal population in stored-crushed corn. | ||||||||||||||||||||
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Naphthol AS-D | Naphthol AS-D, in the form of its chloroacetate, can be used to demonstrate the esterase activity of human myeloid cells and contribute to research related to white blood cells. | |||||||||||||||||||||
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Naphthol AS-BS | 99.12% | Naphthol AS-BS (Compound 1) is a human cytomegalovirus (HCMV) DNA polymerase alpha inhibitor with an IC50 of 12 μM. Naphthol AS-BS can be used for the research of infection. | ||||||||||||||||||||
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ALR2-IN-10 | ALR2-IN-10 (Compound 23) is a weak Aldose Reductase 2 inhibitor with inhibition rate of 6% at 27 μM. ALR2-IN-10 can be used for the research of diabetic complication. | |||||||||||||||||||||
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