929622-08-2
929622-08-2
Chemical Structure
Bavisant
Synonym(s): JNJ-31001074
- CAS No.: 929622-08-2
- Formula:C19H27N3O2
- Molecular Weight:329.44
IUPAC Name: (4-cyclopropylpiperazin-1-yl)(4-(morpholinomethyl)phenyl)methanone
InChIKey: BGBVSGSIXIIREO-UHFFFAOYSA-N
SMILES: O=C(N1CCN(C2CC2)CC1)C(C=C3)=CC=C3CN4CCOCC4
Biological Activity: Bavisant (JNJ-31001074) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3].
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Bavisant | 98.81% | Bavisant (JNJ-31001074) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant can be used for attention-deficit hyperactivity disorder (ADHD) research. | ||||||||||||||||||||
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References
- [1]. Hudkins RL, et al. Discovery and characterization of 6-{4-[3-(R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one (CEP-26401, irdabisant): a potent, selective histamine H3 receptor inverse agonist. J Med Chem. 2011 Jul 14;54(13):4781-92. [Content Brief]
- [2]. Weisler RH, et al. Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34. [Content Brief]
- [3]. Ghoshal A, et al. Identification of novel β-lactams and pyrrolidinone derivatives as selective Histamine-3 receptor (H3R) modulators as possible anti-obesity agents. Eur J Med Chem. 2018 May 25;152:148-159. [Content Brief]
