939-19-5
939-19-5
Chemical Structure
3-Hydroxycoumarin
- CAS No.: 939-19-5
- Formula:C9H6O3
- Molecular Weight:162.14
IUPAC Name: 3-hydroxy-2H-chromen-2-one
InChIKey: MJKVTPMWOKAVMS-UHFFFAOYSA-N
SMILES: O=C1C(O)=CC2=CC=CC=C2O1
Biological Activity: 3-Hydroxycoumarin is an inhibitor of tyrosinase and lipoxygenase with an IC50 for recombinant human tyrosinase (rHT) of 26 μM, and a Ki of 3.39 μM; its IC50 for LOX is 9.5 μM. 3-Hydroxycoumarin has DPPH free radical scavenging activity (IC50 = 31.2 μM). 3-Hydroxycoumarin has photoprotective effects on sea urchin zygotes and embryos[1][2][3][4].
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3-Hydroxycoumarin | 99.30% | 3-Hydroxycoumarin is an inhibitor of tyrosinase and lipoxygenase with an IC50 for recombinant human tyrosinase (rHT) of 26 μM, and a Ki of 3.39 μM; its IC50 for LOX is 9.5 μM. 3-Hydroxycoumarin has DPPH free radical scavenging activity (IC50 = 31.2 μM). 3-Hydroxycoumarin has photoprotective effects on sea urchin zygotes and embryos. | ||||||||||||||||||||
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3-Hydroxycoumarin (Standard) | 98.26% | 3-Hydroxycoumarin (Standard) is the analytical standard of 3-Hydroxycoumarin. This product is intended for research and analytical applications. 3-hydroxycoumarin is a potent and redox inhibitor of human 15-LOX-1. 3-hydroxycoumarin is recently demonstrated to protect sea urchin reproductive cells against ultraviolet B damage. | ||||||||||||||||||||
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References
- [1]. Alavi SJ, Sadeghian H, Seyedi SM, Salimi A, Eshghi H. A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarin. Chem Biol Drug Des. 2018;91(6):1125‐1132. [Content Brief]
- [2]. Asthana S, et al. Structure-Activity Relationship Study of Hydroxycoumarins and Mushroom Tyrosinase. J Agric Food Chem. 2015;63(32):7236‐7244. [Content Brief]
- [3]. de Araujo Leite JC, et al. Photoprotective effect of coumarin and 3-hydroxycoumarin in sea urchin gametes and embryonic cells. J Photochem Photobiol B. 2015 May;146:44-51. [Content Brief]
- [4]. Schlich M, et al. 3-hydroxycoumarin loaded vesicles for recombinant human tyrosinase inhibition in topical applications. Colloids Surf B Biointerfaces. 2018 Nov 1;171:675-681. [Content Brief]
