95415-84-2
Chemical Structure
Gramine-d2
Synonym(s): Donaxine-d2
- CAS No.: 95415-84-2
- Formula:C11H12D2N2
- Molecular Weight:176.25
IUPAC Name: 6-(bis(methyl-d3)amino)-3-cyclohexyl-1-methyl-1,3,5-triazine-2,4(1H,3H)-dione
InChIKey: OCDGBSUVYYVKQZ-MGVXTIMCSA-N
SMILES: CN(C)C([2H])([2H])C1=CNC2=CC=CC=C12
Biological Activity: Gramine-d2 is the deuterium labeled Gramine[1]. Gramine (Donaxine) is a natural alkaloid isolated from giant reed[2], acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively[2]. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist[3]. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties[2].
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Gramine-d2 | Gramine-d2 is the deuterium labeled Gramine. Gramine (Donaxine) is a natural alkaloid isolated from giant reed, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties. | |||||||||||||||||||||
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Gramine (Standard) | 98.95% | Gramine (Standard) is the analytical standard of Gramine. This product is intended for research and analytical applications. Gramine (Donaxine) is an alkaloid, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties. | ||||||||||||||||||||
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Gramine | 99.80% | Gramine (Donaxine) is an alkaloid, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Sun Y, et al. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One. 2013 May 14;8(5):e63354. [Content Brief]
- [3]. Chikazawa M, et al. Identification of Functional Food Factors as β2-Adrenergic Receptor Agonists and Their Potential Roles in Skeletal Muscle. J Nutr Sci Vitaminol (Tokyo). 201864(1):68-74. [Content Brief]
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