5-Bromo-N,N-dimethyltryptamine
5-Bromo-N,N-dimethyltryptamine (5-Bromo-N,N-DMT) is a 5-HT receptor ligand with Ki values of 2.6 nM and 8.3 nM for 5-HT1D and 5-HT7, respectively. 5-Bromo-N,N-dimethyltryptamine induces sedative/hypolocomotor effects. 5-Bromo-N,N-dimethyltryptamine can be used for research on depression.
For research use only. We do not sell to patients.
- CAS No.: 17274-65-6
- Formula: C12H15BrN2
- Molecular Weight:267.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
5-HT1A Receptor 9.6 nM (Ki) |
5-HT2B Receptor 27.0 |
5-HT6 Receptor 22 nM (Ki) |
5-HT7 Receptor 8.3 nM (Ki) |
5-HT1B Receptor 19 nM (Ki) |
5-HT1D Receptor 2.6 nM (Ki) |
5-HT1E Receptor 398 nM (Ki) |
5-HT3 Receptor 1374 nM (Ki) |
5-HT5A Receptor 1038 nM (Ki) |
In Vitro
5-Bromo-N,N-dimethyltryptamine (2d) binds to cloned serotonin receptor subtypes with nanomolar affinity, most potently at 5-HT1D (Ki 2.6 nM) and 5-HT7 (Ki 8.3 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
5-Bromo-N,N-dimethyltryptamine (1-20 mg/kg; i.p.; single administration) lacks antidepressant-like activity in the mouse forced swim test and produces a sedative-like reduction in locomotor activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss Webster (adult male, 8 weeks old, 24-31 g)[1]
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Dosage:10 mg/kg, 20 mg/kg, and 40 mg/kg
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Administration:i.p.; single injection
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Result:In the forced swim test, compound 2d immobility time was 103 sec at 10 mg/kg, 110.8 sec at 20 mg/kg, and 52.4 sec at 40 mg/kg.
In the locomotor activity test, compound 2d total locomotor activity was 1141 at 10 mg/kg, 521 at 20 mg/kg, and 73 at 40 mg/kg.
Did not show antidepressant-like action in the initial 20 mg/kg evaluation, and at 40 mg/kg it reduced immobility in the forced swim test while also decreasing locomotor activity.
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Animal Model:Swiss Webster (male; Harlan, Indianapolis, IN; 25-30 g)[2]
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Dosage:1-20 mg/kg
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Administration:i.p.; single administration
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Result:Did not exhibit antidepressant-like activity in the forced swim test.
It caused a significant reduction of locomotor activity indicative of a potential sedative action.
Chemical Information
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CAS No. 17274-65-6
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Molecular Weight 267.16
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Formula C12H15BrN2
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SMILES
BrC1=CC2=C(NC=C2CCN(C)C)C=C1
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Synonyms
5-Bromo-N,N-DMT
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5-Bromo-N,N-dimethyltryptamine Related Classifications
HY-W296398 Related Classifications
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