CDD-3155
CDD-3155 is a serine/threonine kinase 33 (STK33) inhibitor that binds to human STK33 with Kd = 0.863 nM. CDD-3155 can serve as a biochemical tool for the male germ cell kinase required for late spermatogenesis.
For research use only. We do not sell to patients.
- CAS No.: 3086536-64-0
- Formula: C31H29N5O2
- Molecular Weight:503.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
STK33 0.863 nM (Kd) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
1830 nM
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Inhibition of NanoLuc-tagged STK33 in transiently transfected HEK293T cells assessed by NanoBRET target engagement assay after 2 hrs compound incubation.
Inhibition of NanoLuc-tagged STK33 in transiently transfected HEK293T cells assessed by NanoBRET target engagement assay after 2 hrs compound incubation.
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acs.jmedchem.6c00790 |
| HEK-293T | IC50 |
26700 nM
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Inhibition of NanoLuc-tagged CLK4 in transiently transfected HEK293T cells assessed by NanoBRET target engagement assay after 2 hrs compound incubation.
Inhibition of NanoLuc-tagged CLK4 in transiently transfected HEK293T cells assessed by NanoBRET target engagement assay after 2 hrs compound incubation.
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acs.jmedchem.6c00790 |
In Vitro
CDD-3155 (serial dilution from 40 μM to 0.4 nM; compound incubation for 2 h; transfection for 36 h) inhibits STK33 in HEK293T cells with an IC50 value of 1830 nM and exhibits 14.6-fold cellular preference for CLK4[1].
The kinetic solubility of CDD-3155 (4 μL of 10 mM DMSO stock solution added to 196 μL PBS; incubated at 25°C for 1 h) in PBS at pH 7.4 is 151 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3086536-64-0
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Molecular Weight 503.59
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Formula C31H29N5O2
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SMILES
O=C(C1=CC=CC=C1C2=CC=CC=C2C#CC3=NNC4=C3C=C(C(N5CC6(CNCCC6)C5)=O)C=C4)NC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDD-3155 Related Classifications
HY-190878 Related Classifications
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