2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. CDK9-IN-18

CDK9-IN-18 is a potent CDK9 inhibitor. CDK9-IN-18 blocks the phosphorylation function of kinase CDK9. CDK9-IN-18 exhibits both good anticancer activity and low cellular activity. CDK9-IN-18 induces apoptosis.

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CDK9-IN-18

CDK9-IN-18 화학구조

CAS No. : 1804127-83-0

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CDK9-IN-18 Related Antibodies

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제품 설명

CDK9-IN-18 is a potent CDK9 inhibitor. CDK9-IN-18 blocks the phosphorylation function of kinase CDK9. CDK9-IN-18 exhibits both good anticancer activity and low cellular activity. CDK9-IN-18 induces apoptosis.

In Vitro

CDK9-IN-18 (compound 12i) (0-20 μM, 3 hours; NH2 cells) suppress both HIV-1 transcription and the phosphorylation at Serine 2 of the RNAPII CTD in a dose-dependent manner[1].
CDK9-IN-18 (compound 12i) (0-5.0 μM, 24 hours; human tumor cell lines) exerts antiproliferative effect through the induction of apoptosis in HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CDK9-IN-18 Related Antibodies

Western Blot Analysis[1]

Cell Line: NH2 cells
Concentration: 0.1, 0.2, 0.5, 1.0 and 2.0 μM
Incubation Time: 3 hours
Result: P-Ser2 level of RNAPII CTD decreased in a dose-dependent fashion.

Cell Cytotoxicity Assay[1]

Cell Line: A375 (skin cancer), A549 (lung cancer), HepG2 (liver cancer) and MCF-7 (breast cancer)
Concentration: 2.0 μM
Incubation Time: 24 hours
Result: Inhibited with IC50 values of 0.10, 0.53, 0.07 and 0.10 μM for A375, A549, HepG2 and MCF-7 cells, respectively.

Western Blot Analysis[1]

Cell Line: A375 (skin cancer), A549 (lung cancer), HepG2 (liver cancer) and MCF-7 (breast cancer)
Concentration: 0.1, 0.2, 0.5, 1.0, 2.0 and 5.0 μM
Incubation Time: 24 hours
Result: The expression level of the specific apoptosisassociated protein (cleaved PARP) increased in a dose-dependent fashion.

Cell Cytotoxicity Assay[1]

Cell Line: HepG2 cells
Concentration: 1.0 and 5.0 μM
Incubation Time: 24 hours
Result: The percentage of cells in late apoptosis was recorded as 24.2% and 36.3% at 1.0 and 5.0 μM concentrations, respectively.
분자량

472.50

화학식

C27H20N8O
CAS No.
SMILES

O=C(C(N1)=CC2=C1C=CC(NC3=NC=CC(C4=CC=CN=C4)=N3)=C2)N/N=C/C5=CNC6=C5C=CC=C6
선적

Room temperature in continental US; may vary elsewhere.
보관

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순도&문서
References
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CDK9-IN-18 Related Classifications

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Keywords:

CDK9-IN-181804127-83-0CDKApoptosisCyclin dependent kinaseCDK9apoptosisanticancerInhibitorinhibitorinhibit

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