Cercosporin
Based on 1 Customer Validation
Cercosporin is produced by a plant pathogen, Pseudocercosporella capsellae. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations. Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC50 of 0.6-1.3 μM.
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- Reinheit: 98.90%
- CAS. Nr.: 35082-49-6
- Formel: C29H26O10
- Molecular Weight:534.51
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
IC50: 0.6-1.3 μM (PKC)[2]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BT-549 | IC50 |
10.8 μM
Compound: 5
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Cytotoxicity against human BT549 cells assessed as viable cells by neutral red dye method
Cytotoxicity against human BT549 cells assessed as viable cells by neutral red dye method
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[PMID: 22530813] |
| KB | IC50 |
7.1 μM
Compound: 5
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Cytotoxicity against human KB cells assessed as viable cells by neutral red dye method
Cytotoxicity against human KB cells assessed as viable cells by neutral red dye method
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[PMID: 22530813] |
| SK-MEL | IC50 |
3.6 μM
Compound: 5
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Cytotoxicity against human SK-MEL cells assessed as viable cells by neutral red dye method
Cytotoxicity against human SK-MEL cells assessed as viable cells by neutral red dye method
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[PMID: 22530813] |
| SK-OV-3 | IC50 |
3.7 μM
Compound: 5
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Cytotoxicity against human SKOV3 cells assessed as viable cells by neutral red dye method
Cytotoxicity against human SKOV3 cells assessed as viable cells by neutral red dye method
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[PMID: 22530813] |
In Vitro
Cercosporin (0.8-8.0 μM; 30 s, 60 s, 90 s, 120 s) photodynamic therapy (PDT) effect is stronger in T98G cells than in U87 or MCF7 cells, the LD50 value for the T98G cells (0.14 J cm2) is much less than the LD50 value for MCF-7 and U87 cell lines (0.26 and 0.24 J cm2, respectively)[1]. Cercosporin (0-3 μΜ; 24 hours) interplays with copper results in a synergistic cytotoxicity in MCF7 and T98G cells, that is, S(CuSO4 + Cerco) S(CuSO4) x S(Cerco), barely has an additive effect in U87 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human GBM cell lines, T98G and U87; Breast carcinoma cell line, MCF-7
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Concentration:0 μM, 1 μM, 2 μM, 3 μM
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Incubation Time:24 hours
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Result:Exhibited a synergistic cytotoxicity with copper only in the most respiratory cell lines (MCF-7 and T98G).
Chemical Information
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CAS. Nr. 35082-49-6
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Appearance Solid
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Molecular Weight 534.51
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Formel C29H26O10
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Color Brown to reddish brown
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SMILES
O=C1C=C(C(C2=C34)=C5C1=C(O)C(OC)=C(C[C@H](O)C)C5=C4C(C[C@H](O)C)=C6OC)OCOC2=CC(O)=C3C6=O
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Synonyms
CGP049090
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Structure Classification
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Initial Source
Pseudocercosporella capsellae
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : ≥ 10 mg/mL (18.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (284 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Mastrangelopoulou M, et al. Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines. Photochem Photobiol. 2019 Jan;95(1):387-396. [Content Brief]
[2]. Morgan BJ, et al. Design, synthesis, and investigation of protein kinase C inhibitors: total syntheses of (+)-calphostin D, (+)-phleichrome, cercosporin, and new photoactive perylenequinones. J Am Chem Soc. 2009 Jul 8;131(26):9413-25. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8709 mL | 9.3544 mL | 18.7087 mL | 46.7718 mL |
| 5 mM | 0.3742 mL | 1.8709 mL | 3.7417 mL | 9.3544 mL | |
| 10 mM | 0.1871 mL | 0.9354 mL | 1.8709 mL | 4.6772 mL | |
| 15 mM | 0.1247 mL | 0.6236 mL | 1.2472 mL | 3.1181 mL |
Cercosporin Related Classifications
HY-N6743 Related Classifications
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