1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. Cercosporin

Cercosporin 

Cat. No.: HY-N6743
Handling Instructions

Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes, pigments of the elsinoe family of fungi. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations. Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC50 of 0.6-1.3 μM.

For research use only. We do not sell to patients.

Cercosporin Chemical Structure

Cercosporin Chemical Structure

CAS No. : 35082-49-6

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Description

Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes, pigments of the elsinoe family of fungi. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations[1]. Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC50 of 0.6-1.3 μM[2].

IC50 & Target

IC50: 0.6-1.3 μM (PKC)[2]

In Vitro

Cercosporin (0.8-8.0 μM; 30 s, 60 s, 90 s, 120 s) photodynamic therapy (PDT) effect is stronger in T98G cells than in U87 or MCF7 cells, the LD50 value for the T98G cells (0.14 J cm2) is much less than the LD50 value for MCF-7 and U87 cell lines (0.26 and 0.24 J cm2, respectively)[1].
Cercosporin (0-3 μΜ; 24 hours) interplays with copper results in a synergistic cytotoxicity in MCF7 and T98G cells, that is, S(CuSO4 + Cerco) ≪ S(CuSO4) x S(Cerco), barely has an additive effect in U87 cells[1].

Cell Viability Assay[1]

Cell Line: Human GBM cell lines, T98G and U87; Breast carcinoma cell line, MCF-7
Concentration: 0 μM, 1 μM, 2 μM, 3 μM
Incubation Time: 24 hours
Result: Exhibited a synergistic cytotoxicity with copper only in the most respiratory cell lines (MCF-7 and T98G).
Molecular Weight

534.51

Formula

C₂₉H₂₆O₁₀

CAS No.

35082-49-6

SMILES

COC(C1=O)=C(C2=C3C(C4=C(C(OC)=C3CC(O)C)O)=C5C(OCOC6=C5C2=C1C(O)=C6)=CC4=O)CC(C)O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Cercosporin
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