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Cat. No.: HY-18016

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CGI 560

CGI 560 is an inhibitor for Bruton's tyrosine kinase (BTK) with an IC₅₀ of 400 nM.

For research use only. We do not sell to patients.

CAS No.: 845269-74-1
Formula: C₂₉H₂₇N₅O
Molecular Weight:461.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CGI 560 Chemical Structure

CAS No.: 845269-74-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

CGI 560 is an inhibitor for Bruton's tyrosine kinase (BTK) with an IC₅₀ of 400 nM.

IC₅₀ & Target

IC₅₀: 400 nM (Bruton's tyrosine kinase)

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	400 nM Compound: CGI-560	Inhibition of C-terminal V5-His6 tagged human full-length Btk expressed in Sf9 cells by Lanthascreen assay Inhibition of C-terminal V5-His6 tagged human full-length Btk expressed in Sf9 cells by Lanthascreen assay	[PMID: 30881616]

Chemical Information

CAS No. 845269-74-1
Molecular Weight 461.56
Formula C₂₉H₂₇N₅O
SMILES

O=C(C1=CC=C(C(C)(C)C)C=C1)NC2=CC(C3=CN4C(C(NC5=CC=CC=C5)=N3)=NC=C4)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lv J, et al., Development of Bruton's Tyrosine Kinase Inhibitors for Rheumatoid Arthritis. Curr Med Chem. 2018;25(42):5847-5859. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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