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  4. CGS 21680 sodium

CGS 21680 (sodium) is a biochemical assay reagent.

For research use only. We do not sell to patients.

CAS No. : 120225-64-1

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CGS 21680 sodium Related Antibodies

Top Publications Citing Use of Products

    CGS 21680 sodium purchased from MedChemExpress. Usage Cited in: Nature. 2026 Jan;649(8096):423-431.  [Abstract]

    Immobility time in forced swimming test 30 minutes after intraperitoneal (i.p.) injection of an A1 receptor agonist (CHA; 0.1 mg/kg) or an A2A receptor agonist (CGS 21680 Hydrochloride; 0.1 mg/kg) in chronic restraint stress (CRS) mice.

    CGS 21680 sodium purchased from MedChemExpress. Usage Cited in: Nature. 2026 Jan;649(8096):423-431.  [Abstract]

    Twenty-four hours after intraperitoneal injection of CHA or CGS21680 (CGS 21680 Hydrochloride; 0.1 mg/kg) into CRS mice, immobility time and sucrose preference in the forced swimming test were measured.

    CGS 21680 sodium purchased from MedChemExpress. Usage Cited in: Nature. 2026 Jan;649(8096):423-431.  [Abstract]

    Concentrations of CHA and CGS 21680 Hydrochloride in serum (top) and brain tissue (bottom) at 30 min and 24 h after i.p. injection, measured by LC-MS. Data are mean ± s.e.m.

    CGS 21680 sodium purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2025 May 21:101539.  [Abstract]

    Percentage quantification of ASCs after 3 days of treatment with the A2aR agonist CGS 21680 Hydrochloride (1 μM) with or without Inosine (250 μM).

    CGS 21680 sodium purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2025 Mar;29(5):e70458.  [Abstract]

    Schematic illustration showed that CGS 21680 Hydrochloride (1 mg/kg) or dimethyl sulfoxide (DMSO) was instilled combined with LPS (5 mg/kg) challenge for 24 h.

    CGS 21680 sodium purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2025 Mar;29(5):e70458.  [Abstract]

    WT and Mac‐A2aR‐KO mice were treated with LPS (5 mg/kg) and CGS 21680 Hydrochloride (1 mg/kg) or PBS for 24 h. Assessment of kidney oedema (n = 3).

    CGS 21680 sodium purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2025 Mar;29(5):e70458.  [Abstract]

    Intracellular total ROS was detected in PMA‐differentiated THP‐1 cells treated with vehicle, CGS 21680 Hydrochloride (10 nM), LPS (1 μg/mL) or LPS after 30 min CGS 21680 Hydrochloride pretreatment (n = 3).

    CGS 21680 sodium purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2025 Mar;29(5):e70458.  [Abstract]

    Intracellular total ROS was detected in PMA‐differentiated THP‐1 cells treated with vehicle, LPS (100 μg/mL) and interferon‐gamma (IFN‐γ) (20 ng/mL) with or without 30 min CGS 21680 Hydrochloride pretreatment before; interleukin (IL)‐4 (20 ng/mL) and IL‐13 (20 ng/mL) with or without 30 min CGS 21680 Hydrochloride pretreatment before (n = 3).

    CGS 21680 sodium purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2023 Jan 1:249:114410.  [Abstract]

    CGS21680 (10 μM) elevates the expression level of A2aR protein in A549 cells.

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    Description

    CGS 21680 (sodium) is a biochemical assay reagent.

    Molecular Weight

    521.50

    Formula

    C23H28N7NaO6
    CAS No.
    SMILES

    O[C@H]1[C@@H](O[C@@H]([C@H]1O)C(NCC)=O)N2C3=NC(NCCC4=CC=C(C=C4)CCC(O[Na])=O)=NC(N)=C3N=C2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
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    CGS 21680 sodium Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    CGS 21680120225-64-1CGS21680CGS-21680Biochemical Assay ReagentsInhibitorinhibitorinhibit

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