Art. -Nr.: HY-136064

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4,4'-Dimethoxychalcone

4 Cited Publications

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4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties.

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Reinheit: 99.57%
CAS. Nr.: 2373-89-9
Formel: C₁₇H₁₆O₃
Molecular Weight:268.31

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

4,4'-Dimethoxychalcone Chemical Structure

CAS. Nr.: 2373-89-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties^[1].

IC₅₀ & Target

Autophagy^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	15 μM Compound: 2yy	Antiproliferative activity against human K562 cells after 5 days by MTT assay Antiproliferative activity against human K562 cells after 5 days by MTT assay	[PMID: 19837593]
THP-1	IC₅₀	15.39 nM Compound: 3c	Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagulant activity incubated for 1 hr prior to LPS-challenge measured after 5 hr by spectrophotometric analysis Inhibition of tissue factor in Homo sapiens (human) THP1-cells using factor 10a chromogenic substrate assessed as inhibition of LPS-iduced procoagulant activity incubated for 1 hr prior to LPS-challenge measured after 5 hr by spectrophotometric analysis	10.1007/s00044-012-0330-5

In Vivo

The flavonoid 4,4'-Dimethoxychalcone acts as an anti-ageing compound with cardioprotective effects in mice and the potential to promote longevity across species^[1].
4,4'-Dimethoxychalcone (100 mg/kg; intraperitoneally) efficiently triggered autophagic flux in the heart and liver from wild type (WT) C57BL/6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

6-week-old male wild type C57BL/6 or Atg4b^-/- mice^[1]
Dosage:

100 mg/kg
Administration:

Injected intraperitoneally with a single
Result:

Triggered autophagic flux in the heart and liver.

Chemical Information

CAS. Nr. 2373-89-9
Appearance Solid
Molecular Weight 268.31
Formel C₁₇H₁₆O₃
Color Light yellow to yellow
SMILES

O=C(C1=CC=C(OC)C=C1)/C=C/C2=CC=C(OC)C=C2
Structure Classification
- Flavonoids
- Chalcones
Initial Source
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (4)

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Journal Impact Factor

Food Chem

Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]

2025 Dec 30:497:146992. PMID: 41285060
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 May 31:489:144992. PMID: 40466530
Int Immunopharmacol

4,4'-Dimethoxychalcone ameliorates estrogen-deficient osteoporosis by targeting PTP1B to inhibit the c-Src/NFATc1 signaling axis. [Abstract]

2026 Mar 1:172:116233. PMID: 41548437
Eur J Pharmacol

4,4'-dimethoxychalcone exerts neuroprotective effects in Alzheimer's disease mice by activating the Keap1/Nrf2 signaling pathway. [Abstract]

2026 Feb 28:1016:178617. PMID: 41620006

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 250 mg/mL (931.76 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.7270 mL

18.6352 mL

37.2703 mL

5 mM

0.7454 mL

3.7270 mL

7.4541 mL

10 mM

0.3727 mL

1.8635 mL

3.7270 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 6.25 mg/mL (23.29 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 6.25 mg/mL (23.29 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Carmona-Gutierrez D, et al. The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun. 2019 Feb 19;10(1):651. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.7270 mL	18.6352 mL	37.2703 mL	93.1758 mL
	5 mM	0.7454 mL	3.7270 mL	7.4541 mL	18.6352 mL
	10 mM	0.3727 mL	1.8635 mL	3.7270 mL	9.3176 mL
	15 mM	0.2485 mL	1.2423 mL	2.4847 mL	6.2117 mL
	20 mM	0.1864 mL	0.9318 mL	1.8635 mL	4.6588 mL
	25 mM	0.1491 mL	0.7454 mL	1.4908 mL	3.7270 mL
	30 mM	0.1242 mL	0.6212 mL	1.2423 mL	3.1059 mL
	40 mM	0.0932 mL	0.4659 mL	0.9318 mL	2.3294 mL
	50 mM	0.0745 mL	0.3727 mL	0.7454 mL	1.8635 mL
	60 mM	0.0621 mL	0.3106 mL	0.6212 mL	1.5529 mL
	80 mM	0.0466 mL	0.2329 mL	0.4659 mL	1.1647 mL
	100 mM	0.0373 mL	0.1864 mL	0.3727 mL	0.9318 mL

Keywords

4,4'-Dimethoxychalcone

4 Cited Publications

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4,4'-Dimethoxychalcone

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Publications Citing Use of MedChemExpress (MCE) 4,4'-Dimethoxychalcone

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

4,4'-Dimethoxychalcone

Natural Product Library

Autophagy Compound Library

Medicine Food Homology Compound Library

Traditional Chinese Medicine Active Compound Library

Flavonoids Library

Targeted Diversity Library

Plant-Sourced Natural Product Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mongolian Medicine Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) 4,4'-Dimethoxychalcone

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

4,4'-Dimethoxychalcone Related Classifications

HY-136064 Related Classifications