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Art. -Nr.: HY-U00153

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Dixyrazine

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Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate.

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Reinheit: 99.87%
CAS. Nr.: 2470-73-7
Formel: C₂₄H₃₃N₃O₂S
Molecular Weight:427.60

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Dixyrazine Chemical Structure

CAS. Nr.: 2470-73-7

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Protokoll
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate.

In Vivo

Pretreatment with Dixyrazine 10 mg/kg completely prevents the brain oedema and significantly reduces the albumin increase in cerebrospinal fluid (CSF)^[1]. The phenothiazine Dixyrazine (5 mg/kg i.v.) has minimal, transient hypotensive effects but significantly reduces the leakage of ¹²⁶I labelled serum albumin in conscious rats subjected to acute hypertension provoked by i.v. Adrenaline or Bicuculline. The diameters of pial arteries and veins are continuously measured with a multichannel videoangiometer through a closed cranial window in anesthetized rats before and after i.v. injection of Dixyrazine (5 mg/kg). Dixyrazine, 5 mg /kg, induces a slight transitory decrease in blood pressure (10-20 mm Hg). Maximum MAP is slightly but not significantly lower in Dixyrazine-treated rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2470-73-7
Appearance Solid
Molecular Weight 427.60
Formel C₂₄H₃₃N₃O₂S
Color White to off-white
SMILES

CC(CN1C2=C(C=CC=C2)SC3=CC=CC=C13)CN4CCN(CCOCCO)CC4
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (233.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3386 mL

11.6932 mL

23.3863 mL

5 mM

0.4677 mL

2.3386 mL

4.6773 mL

10 mM

0.2339 mL

1.1693 mL

2.3386 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Protokoll

Animal Administration^[2]

Rats^[2]
Male Sprague-Dawley rats (200-225 g) are used. Evans blue and ¹²⁵I-HSA are used as tracers, and controls are compared to rats pretreated with Dixyrazine 5 mL/kg or 15 mg/kg. The lower dose is given 15-20 min before the infusion of urea (that is the same interval as in the hypertension experiments). Because of larger effects on blood pressure with higher doses, the interval has to be extended to 40 min in this group. The radioactivity is determined in the right and left hemisphere and related to the activity in the blood.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Westergren I, et al. Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate. Acta Neurochir (Wien). 1991;113(3-4):171-5. [Content Brief]

[2]. Johansson BB, et al. Phenothiazine-mediated protection of the blood-brain barrier during acute hypertension. Stroke. 1982 Mar-Apr;13(2):220-5. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3386 mL	11.6932 mL	23.3863 mL	58.4659 mL
	5 mM	0.4677 mL	2.3386 mL	4.6773 mL	11.6932 mL
	10 mM	0.2339 mL	1.1693 mL	2.3386 mL	5.8466 mL
	15 mM	0.1559 mL	0.7795 mL	1.5591 mL	3.8977 mL
	20 mM	0.1169 mL	0.5847 mL	1.1693 mL	2.9233 mL
	25 mM	0.0935 mL	0.4677 mL	0.9355 mL	2.3386 mL
	30 mM	0.0780 mL	0.3898 mL	0.7795 mL	1.9489 mL
	40 mM	0.0585 mL	0.2923 mL	0.5847 mL	1.4616 mL
	50 mM	0.0468 mL	0.2339 mL	0.4677 mL	1.1693 mL
	60 mM	0.0390 mL	0.1949 mL	0.3898 mL	0.9744 mL
	80 mM	0.0292 mL	0.1462 mL	0.2923 mL	0.7308 mL
	100 mM	0.0234 mL	0.1169 mL	0.2339 mL	0.5847 mL

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Protokoll
Reinheit & Dokumentation
Verweise

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Dixyrazine

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Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

FDA-Approved Drug Library

Drug Repurposing Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Protokoll

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Dixyrazine

FDA Approved & Pharmacopeial Drug Library

Human Metabolite Library

Off-patent Drug Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

FDA-Approved Drug Library

Drug Repurposing Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Protokoll

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Dixyrazine Related Classifications

HY-U00153 Related Classifications