Art. -Nr.: HY-100529

PD150606

14 Cited Publications

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Based on 14 publication(s) in Google Scholar

PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with K_i values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective.

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Reinheit: 98.61%
CAS. Nr.: 179528-45-1
Formel: C₉H₇IO₂S
Molecular Weight:306.12

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

PD150606 Chemical Structure

CAS. Nr.: 179528-45-1

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (14)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with K_i values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective^[1].

IC₅₀ & Target

Ki: 0.21 μM (μ-calpains), 0.37 μM (m-calpains)^[1]

In Vitro

PD150606 interacts with both calcium-binding domains (μ- and m-calpains) of Calpain^[1].
PD150606 attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices^[1].
PD 150606 (25 μM; 0-12 hours) reduces Cycloheximide (10 mg/ml) -triggered apoptosis of neutrophils^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 179528-45-1
Appearance Solid
Molecular Weight 306.12
Formel C₉H₇IO₂S
Color Off-white to yellow
SMILES

O=C(O)/C(S)=C/C1=CC=C(I)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (14)

All IFCell Imaging/StainingWB

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Journal Impact Factor

Nature

STING agonist-based ER-targeting molecules boost antigen cross-presentation. [Abstract]

2025 May;641(8061):202-210. PMID: 40140567
Mol Cancer

Sulindac (K-80003) with nab-paclitaxel and gemcitabine overcomes drug-resistant pancreatic cancer. [Abstract]

2024 Sep 30;23(1):215. PMID: 39350121

PD150606 purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2024 Sep 30;23(1):215. [Abstract]

Western blot analysis of RXRα expression after 24 h of treatment with PD150606 (200 nM, m-calpain inhibitor) or ZFY-CHO (10 µM, CTSL inhibitor).
J Hazard Mater

Chlorpyrifos triggers epithelioma papulosum cyprini cell pyroptosis via miR-124-3p/CAPN1 axis. [Abstract]

2022 Feb 15;424(Pt A):127318. PMID: 34879549
Pharmacol Res

TRPC1 contributes to endotoxemia-induced myocardial dysfunction via mediating myocardial apoptosis and autophagy. [Abstract]

2022 May 19;181:106262. PMID: 35598715
Apoptosis

Regulated cell death environments drive fibroinflammatory reprogramming in surviving adipose-derived stem cells. [Abstract]

2025 Sep 30. PMID: 41028407
J Genet Genomics

Yki stability and activity are regulated by Ca2+-calpains axis in Drosophila. [Abstract]

2024 Oct;51(10):1020-1029. PMID: 38663479
Cell Rep

Cell-cell and cell-matrix adhesion regulated by Piezo1 is critical for stiffness-dependent DRG neuron aggregation. [Abstract]

2023 Dec 2;42(12):113522. PMID: 38048221

PD150606 purchased from MedChemExpress. Usage Cited in: Cell Rep. 2023 Dec 2;42(12):113522. [Abstract]

Representative immunofluorescence images of DRG neurons seeded on laminin-coated glass slides and treated with culture medium (control), 10 μM PD150606 or 30 μM Yoda1 for 24 hours.

PD150606 purchased from MedChemExpress. Usage Cited in: Cell Rep. 2023 Dec 2;42(12):113522. [Abstract]

Western blots of integrin-β1, SN25, and GAPDH in DRG neurons seeded on glass slides and treated with 10 μM PD150606 for 30 min at DIV1.

PD150606 purchased from MedChemExpress. Usage Cited in: Cell Rep. 2023 Dec 2;42(12):113522. [Abstract]

Representative images were cultured on substrates at 5.0 and 20 kPa and incubated for 24 hours with medium (control) or 10 μM PD150606.
EMBO Rep

The mechanosensitive TRPV2 calcium channel promotes human melanoma invasiveness and metastatic potential. [Abstract]

2023 Apr 5;24(4):e55069. PMID: 36744297
J Cell Physiol

Piezo1 Is Related to the Enamel Matrix Formation in Mouse Tooth Germ Development. [Abstract]

2025 Apr;240(4):e70036. PMID: 40237554
Exp Cell Res

Inhibition of the ERK1/2-ubiquitous calpains pathway attenuates experimental pulmonary fibrosis in vivo and in vitro. [Abstract]

2020 Jun 1;391(1):111886. PMID: 32017927
Toxicol Appl Pharmacol

Inhibition of CDK9 exhibits anticancer activity in hepatocellular carcinoma cells via targeting ribonucleotide reductase. [Abstract]

2023 Jul 15:471:116568. PMID: 37245555
J Peripher Nerv Syst

The NCX1 calcium exchanger is implicated in delayed axotomy after peripheral nerve stretch injury. [Abstract]

2024 Dec;29(4):555-566. PMID: 39402795
Int Heart J

Inhibition of Calpain Alleviates Apoptosis in Coxsackievirus B3-induced Acute Virus Myocarditis Through Suppressing Endoplasmic Reticulum Stress. [Abstract]

2021 Jul 30;62(4):900-909. PMID: 34234076
Research Square Preprint

2024 Jan 2.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 28 mg/mL (91.47 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2667 mL

16.3335 mL

32.6669 mL

5 mM

0.6533 mL

3.2667 mL

6.5334 mL

10 mM

0.3267 mL

1.6333 mL

3.2667 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (8.17 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (8.17 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (8.17 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (641 KB)
- English - EN (641 KB)
- Français - FR (641 KB)
- Deutsch - DE (641 KB)
- Norwegian - NO (641 KB)
- Español - ES (641 KB)
- Swedish - SV (641 KB)
- Italian - IT (641 KB)
- Korean - KR (641 KB)
- Portuguese - PT (641 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. 1. Wang KK et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92. [Content Brief]

[2]. 2. Squier MK , et al. Calpain and calpastatin regulate neutrophil apoptosis. J Cell Physiol. 1999 Mar;178(3):311-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2667 mL	16.3335 mL	32.6669 mL	81.6673 mL
	5 mM	0.6533 mL	3.2667 mL	6.5334 mL	16.3335 mL
	10 mM	0.3267 mL	1.6333 mL	3.2667 mL	8.1667 mL
	15 mM	0.2178 mL	1.0889 mL	2.1778 mL	5.4445 mL
	20 mM	0.1633 mL	0.8167 mL	1.6333 mL	4.0834 mL
	25 mM	0.1307 mL	0.6533 mL	1.3067 mL	3.2667 mL
	30 mM	0.1089 mL	0.5444 mL	1.0889 mL	2.7222 mL
	40 mM	0.0817 mL	0.4083 mL	0.8167 mL	2.0417 mL
	50 mM	0.0653 mL	0.3267 mL	0.6533 mL	1.6333 mL
	60 mM	0.0544 mL	0.2722 mL	0.5444 mL	1.3611 mL
	80 mM	0.0408 mL	0.2042 mL	0.4083 mL	1.0208 mL

Keywords

PD150606

14 Cited Publications

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PD150606

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Anti-diabetic Compound Library

Ubiquitination Compound Library

Neuroprotective Compound Library

Anti-Blood Cancer Compound Library

Targeted Diversity Library

Protease Inhibitor Library

Cysteine Targeted Covalent Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) PD150606

Biologische Aktivität

Chemical Information

Publications (14)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

PD150606

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Anti-diabetic Compound Library

Ubiquitination Compound Library

Neuroprotective Compound Library

Anti-Blood Cancer Compound Library

Targeted Diversity Library

Protease Inhibitor Library

Cysteine Targeted Covalent Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) PD150606

Biologische Aktivität

Chemical Information

Publications (14)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

PD150606 Related Classifications

HY-100529 Related Classifications