Paliroden
Based on 1 Customer Validation
Paliroden (SR 57667) is an orally active, non-peptide neuroprotective agent that promotes adult neurogenesis. Paliroden can be used for research on Alzheimer's disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 96.26%
- CAS. Nr.: 188396-77-2
- Formel: C26H24F3N
- Molecular Weight:407.47
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Paliroden (5 mg/kg/day; p.o.; 7 days) enhances reparative neurogenesis after septohippocampal lesion by increasing NSC migration and neuronal differentiation and reversing lesion-induced NeuN+ neuron loss[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat[1]
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Dosage:5 mg/kg
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Administration:p.o.
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Result:Strongly increased proliferation of neural progenitors (BrdU and Ki67 labeling) and their migration and neuronal differentiation in the granular layer of the dentate gyrus (Doublecortin labeling).
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Animal Model:Rat[1]
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Dosage:5 mg/kg/day
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Administration:p.o.; 7 days
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Result:Promoted NSC migration and neuronal differentiation, and reversed injury-induced loss of NeuN+ neurons.
Enhanced reparative neurogenesis following septo-hippocampal injury.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 188396-77-2
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Appearance Solid
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Molecular Weight 407.47
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Formel C26H24F3N
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Color Off-white to light yellow
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SMILES
FC(C1=CC(C2=CCN(CCC3=CC=C(C4=CC=CC=C4)C=C3)CC2)=CC=C1)(F)F
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Synonyms
SR 57667
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Paliroden Related Classifications
HY-101580 Related Classifications
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