YF-2 hydrochloride
Based on 2 publication(s) in Google Scholar
YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.29%
- CAS. Nr.: 1312005-62-1
- Formel: C20H23Cl2F3N2O3
- Molecular Weight:467.31
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Anti-Alzheimer's Disease Compound Library
HY-L069
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Neurodegenerative Disease-related Compound Library
HY-L086
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Anti-Pulmonary Fibrosis Compound Library
HY-L125
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Highly Selective Activators Library
HY-L159
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
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Epigenetics Compound Library
HY-L005
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
HY-L025
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CNS-Penetrant Compound Library
HY-L028
Publications Citing Use of MedChemExpress (MCE) YF-2 hydrochloride
More
Biologische Aktivität
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GCN5/PCAF 29.04 μM (EC50) |
GCN5 49.31 μM (EC50) |
CBP 2.75 μM (EC50) |
YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1312005-62-1
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Appearance Solid
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Molecular Weight 467.31
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Formel C20H23Cl2F3N2O3
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Color White to light yellow
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SMILES
O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C.Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Protein Cell
Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer's disease mice. [Abstract]2024 Apr 1;15(4):261-284. PMID: 38011644 -
Sci Total Environ
Histone hypoacetylation contributes to neurotoxicity induced by chronic nickel exposure in vivo and in vitro. [Abstract]2021 Aug 20:783:147014. PMID: 34088129
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (213.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 3.12 mg/mL (6.68 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.1399 mL | 10.6995 mL | 21.3991 mL | 53.4977 mL |
| 5 mM | 0.4280 mL | 2.1399 mL | 4.2798 mL | 10.6995 mL | |
| DMSO | 10 mM | 0.2140 mL | 1.0700 mL | 2.1399 mL | 5.3498 mL |
| 15 mM | 0.1427 mL | 0.7133 mL | 1.4266 mL | 3.5665 mL | |
| 20 mM | 0.1070 mL | 0.5350 mL | 1.0700 mL | 2.6749 mL | |
| 25 mM | 0.0856 mL | 0.4280 mL | 0.8560 mL | 2.1399 mL | |
| 30 mM | 0.0713 mL | 0.3567 mL | 0.7133 mL | 1.7833 mL | |
| 40 mM | 0.0535 mL | 0.2675 mL | 0.5350 mL | 1.3374 mL | |
| 50 mM | 0.0428 mL | 0.2140 mL | 0.4280 mL | 1.0700 mL | |
| 60 mM | 0.0357 mL | 0.1783 mL | 0.3567 mL | 0.8916 mL | |
| 80 mM | 0.0267 mL | 0.1337 mL | 0.2675 mL | 0.6687 mL | |
| 100 mM | 0.0214 mL | 0.1070 mL | 0.2140 mL | 0.5350 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
YF-2 hydrochloride Related Classifications
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