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Art. -Nr.: HY-187230

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Aceanthrenequinone

Aceanthrenequinone is a polycyclic aromatic hydrocarbon quinone organic compound that belongs to the category of free radical photoinitiators. Aceanthrenequinone serves as an intermediate for dyes and pigments, and also acts as a substrate for organic synthesis and polymer materials. Aceanthrenequinone activates the Aryl Hydrocarbon Receptor pathway, induces the expression of CYP1A protein in the vascular system of zebrafish embryos, and causes the death of embryos at 120 hpf. Aceanthrenequinone is applicable to research related to industrial or biomedical applications.

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CAS. Nr.: 6373-11-1
Formel: C₁₆H₈O₂
Molecular Weight:232.23

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Aceanthrenequinone Chemical Structure

CAS. Nr.: 6373-11-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

CYP1A1

Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen :

In Vitro

ApoptosisOthers

Apoptosis

Aceanthrenequinone (5-100 μM; 24 h non-irradiation or 5 min irradiation + 24 h incubation) induces dose-dependent apoptosis in HEK293T cells, with increased apoptotic cell percentages at higher concentrations under both non-irradiation and 455 nm blue light irradiation conditions, and causes far less necrosis than BAPO^[2].

Others

Aceanthrenequinone (5-100 μM; 24 h non-irradiation) exhibits low cytotoxicity under non-irradiation conditions, with 82.0% relative cell survival at 100 μM after 24 h, causing only slight growth inhibition in HEK293T, LO-2, and BMSCs, and no inhibition in HUVEC-12 cells^[2].
Aceanthrenequinone (5-100 μM; 5 min irradiation + 24 h incubation) cytotoxicity is slightly increased under 455 nm blue light irradiation, with 76.6% and 68.2% relative cell survival at 50 μM and 100 μM respectively after 24 h, but remains much lower than the cytotoxicity of BAPO across HEK293T, HUVEC-12, LO-2, and BMSC cell types^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:

HEK293T, HUVEC-12, LO-2, mouse bone marrow stromal cells (BMSCs)
Concentration:

5, 10, 25, 50, 100 μM
Incubation Time:

24 h (non-irradiation conditions)
Result:

Caused slight growth inhibition in HEK293T, LO-2, and BMSCs (but not HUVEC-12) in a concentration-dependent manner.
Maintained 82.0% relative cell survival rate across tested cell types at 100 μM, which was far higher than the survival rate observed with BAPO at the same concentration.
Made HEK293T cells the most sensitive to AATQ.

Cell Cytotoxicity Assay^[2]

Cell Line:

HEK293T, HUVEC-12, LO-2, mouse bone marrow stromal cells (BMSCs)
Concentration:

5, 10, 25, 50, 100 μM
Incubation Time:

5 min (455 nm blue light irradiation) followed by 24 h incubation
Result:

Increased cytotoxicity relative to non-irradiation conditions, with significant effects observed at 50 and 100 μM.
Resulted in 76.6% relative cell survival at 50 μM and 68.2% relative cell survival at 100 μM.
Showed cytotoxicity substantially lower than that of BAPO under the same irradiation conditions.
Made HEK293T cells remain the most sensitive to AATQ.

Apoptosis Analysis^[2]

Cell Line:

HEK293T cells
Concentration:

5, 10, 25, 50, 100 μM
Incubation Time:

24 h (non-irradiation conditions); 5 min (455 nm blue light irradiation) followed by 24 h incubation
Result:

Slightly increased apoptotic cell numbers at 5 and 10 μM under non-irradiation conditions.
Reached 20.0% late apoptotic/necrotic cells (Q2) and 19.1% early apoptotic cells (Q3) at 100 μM under non-irradiation conditions.
Induced a similar pattern of cell death under irradiation conditions, with apoptotic cell percentages increasing with concentration.
Caused far less necrosis than that induced by BAPO under irradiation conditions.

In Vivo

Aceanthrenequinone (0.8-500 μM; static immersion; 6-120 hpf) exerts extensive developmental toxicity on zebrafish embryos via AHR-related pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

wild type 5D strain (ahr2⁺)^[1]
Dosage:

0.8 μM, 4 μM, 20 μM, 100 μM, 500 μM
Administration:

static immersion; 6-120 hpf
Result:

Induced a broad range of malformations including swim bladder, caudal and pectoral fin, somite, body axis, yolk sac edema, pericardial edema, eye, otic, brain, jaw, snout, and touch response malformations, as well as 120 hpf mortality, with higher EC₅₀ values relative to the most acutely toxic OPAHs.
Induced CYP1A protein expression in the vasculature of exposed embryos.

Related Protocols :

RNA extraction experimental

Chemical Information

CAS. Nr. 6373-11-1
Molecular Weight 232.23
Formel C₁₆H₈O₂
SMILES

O=C1C(C2=C3C1=CC=CC3=CC4=C2C=CC=C4)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Knecht AL, et al. Comparative developmental toxicity of environmentally relevant oxygenated PAHs. Toxicology and applied pharmacology. 2013 Sep 01;271(2):266-75.

[2]. Xiong Y, et al. Characteristics of a novel photoinitiator aceanthrenequinone-initiated polymerization and cytocompatibility of its triggered polymer. Toxicology reports. 2022;9:191-203.

[3]. Klumpp DA, et al. Reactions of Acenaphthenequinone and Aceanthrenequinone with Arenes in Superacid. Applied catalysis. A, General. 2008 Mar 01;336(1-2):128-132.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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