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Art. -Nr.: HY-W1142093

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ActRIIB-IN-4

ActRIIB-IN-4 (Compound 10) is an ActRIIB inhibitor with an IC₅₀ of 4.0 nM. ActRIIB-IN-4 enhances muscle grip strength in tumor cachexia mice.

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CAS. Nr.: 3039974-41-6
Formel: C₂₂H₂₃N₅O₂
Molecular Weight:389.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

ActRIIB-IN-4 Chemical Structure

CAS. Nr.: 3039974-41-6

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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Calculators
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Biologische Aktivität

Beschreibung

ActRIIB-IN-4 (Compound 10) is an ActRIIB inhibitor with an IC₅₀ of 4.0 nM. ActRIIB-IN-4 enhances muscle grip strength in tumor cachexia mice^[1].

Alle TGF-β Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

ActRIIB-IN-4 (0.625-10 μM) exerts a significant reversing effect on C2C12 myotube atrophy, with a reversal rate of 100.3% at 5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ActRIIB-IN-4 (10 mg/kg; i.p.) significantly enhances muscle grip strength in C26 tumor cachexia mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3039974-41-6
Molecular Weight 389.45
Formel C₂₂H₂₃N₅O₂
SMILES

C1(C2=CC=C(OCCN3CCOCC3)C=C2)=CN=C(NC=C4C5=NNC=C5)C4=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Dong, et al. 7-azaindole compounds, preparation method therefor, and use thereof. WO2024114661A1. WIPO (PCT). 2023-11-29.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- In Vitro
- In Vivo
Chemical Information
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ActRIIB-IN-4

Alle TGF-β Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

ActRIIB-IN-4 Related Classifications

HY-W1142093 Related Classifications