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AMG-424

(Synonyms: XmAb968)
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AMG-424 (XmAb968) is a human bispecific antibody (bsAb) targeting CD38 & CD3E. AMG-424 kills CD38-expressing cancer cells, triggers T-cell proliferation and attenuates cytokine release. AMG 424 has antitumor activity in a bone marrow-invasive mouse cancer model and induces peripheral B-cell depletion in cynomolgus monkeys. AMG-424 can be used in multiple myeloma research. Recommended isotype control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

  • Reinheit: 99.32%
  • Molecular Weight:125.012 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for AMG-424
  • Experimental Validation Results for AMG-424
  • Experimental Validation Results for AMG-424
  • AMG-424 Chemical Structure
    AMG-424 Chemical Structure
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AMG-424 Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    half-IGG1-kappa/(scFv-heavy-lambda)-h-CH2-CH3

  • 1/16

    Immobilized Human CD38 Protein, His Tag can bind AMG-424. The EC50 for this effect is 373.8 ng/mL.

  • 1/16

    Immobilized CD3E-His&CD3D without tag can bind AMG-424. The EC50 for this effect is 265.8 ng/mL.

  • AMG-424 Chemical Structure
    1/16
  • AMG-424
  • Immobilized Human CD38 Protein, His Tag can bind AMG-424. The EC50 for this effect is 373.8 ng/mL.
  • Immobilized CD3E-His&CD3D without tag can bind AMG-424. The EC50 for this effect is 265.8 ng/mL.
  • half-IGG1-kappa/(scFv-heavy-lambda)-h-CH2-CH3