Antibacterial agent 337
Antibacterial agent 337 is an antibacterial agent. Antibacterial agent 337 specifically interacts with PG in bacterial cell membranes, triggering membrane disruption, membrane depolarization, increased permeability, cytoplasmic leakage, ROS accumulation and rapid bacterial death. Antibacterial agent 337 inhibits biofilm formation and disrupts mature biofilms. Antibacterial agent 337 exhibits potent in vivo antibacterial efficacy in a mouse model of Staphylococcus aureus skin abscess. Antibacterial agent 337 can be used in studies of Gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus infections, vancomycin-resistant Enterococcus faecalis infections and bacterial biofilm infections.
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- Formel: C78H92Br2N2O4P2
- Molecular Weight:1343.33
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Antibacterial agent 337 (Compound 10 b) (0-64 μg/mL; 8 h for S. aureus, 2 h for HEK293T) selectively neutralizes the anionic surface charge of S. aureus ATCC25923 in a concentration-dependent manner, while exerts no effect on the zeta potential of HEK293T mammalian cells[1].
Antibacterial agent 337 (0-128 μg/mL, 24 h) exhibits potent antibacterial activity against Gram-positive bacteria (S. aureus 25923, S. aureus 43300, E. faecalis 29212, E. faecalis 51299, B. subtilis 9372) with an MIC of 1-4 μg/mL, while shows weak activity against Gram-negative bacteria[1].
Antibacterial agent 337 inhibits biofilm formation of S. aureus ATCC25923, binds specifically to phosphatidylglycerol (PG), and significantly increases ROS[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (male, 6-8 weeks old)[1]
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Dosage:5 mg/kg; 10 mg/kg
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Administration:s.c.; single dose
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Result:Reduced the bacterial load by 1.28 log10 CFU/g (93.38% decrease in bacterial survival) at 5 mg/kg.
Reduced the bacterial load by 2.99 log10 CFU/g (99.89% decrease in bacterial survival) at 10 mg/kg.
Significantly reduced pustule formation and inflammatory infiltration at 5 mg/kg.
Eliminated obvious inflammatory cells in epidermal and dermal layers, with tissue architecture resembling uninfected controls at 10 mg/kg.
Chemical Information
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Molecular Weight 1343.33
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Formel C78H92Br2N2O4P2
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SMILES
C=CCC1=CC=C(OCC(N(CCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)CCCCCC)=O)C(C5=CC=C(OCC(N(CCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)CCCCCC)=O)C(CC=C)=C5)=C1.[Br-].[Br-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Antibacterial agent 337 Related Classifications
HY-182798 Related Classifications
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- Antibacterial agent 337
- Antibacterial agent337
- Antibacterial agent-337
- Bacterial
- Reactive Oxygen Species (ROS)
- methicillin-resistant staphylococcus aureus infection
- gram-positive bacterial infections
- S. aureus ATCC25923
- bacterial membranes
- reactive oxygen species
- HEK293T mammalian cells
- bacterial biofilm infections
- anionic phosphatidylglycerol
- murine S. aureus skin abscess model
- vancomycin-resistant enterococcus faecalis infection
- Inhibitor
- inhibitor
- inhibit