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Art. -Nr.: HY-143303

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Anticancer agent 32

Anticancer agent 32 (compound 2g) is an anticancer agent. Anticancer agent 32 shows anticancer activities, affects cell cycle and induces cell apoptosis. Anticancer agent 32 can be used for the research of cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2222930-76-7
Formel: C₂₄H₂₁F₂N₅O
Molecular Weight:433.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Anticancer agent 32 Chemical Structure

CAS. Nr.: 2222930-76-7

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 17.2 μM (MGC-803), 12.3 μM (HeLa), 40.6 μM (NCI-H460), 46.8 μM (HepG2), 95.4 μM (SMMC-7721), 8.9 μM (T-24), 86.8 μM (HL-7702)^[1]

In Vitro

Anticancer agent 32 (2.5-40 μM; 48 h) shows cytotoxic activities to cancer cell lines^[1].
Anticancer agent 32 (0-16 μM; 24 h) affects cell cycle, induces cell apoptosis, increases intracellular levels of Ca²⁺ and ROS^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

MGC-803, HeLa, NCI-H460, HepG2, SMMC-7721, T-24 and HL-7702 cell lines
Concentration:

2.5, 5, 10, 20 and 40 μM
Incubation Time:

48 hours
Result:

Inhibited cell growth with IC₅₀ values of 17.2, 12.3, 40.6, 46.8, 95.4, 8.9 and 86.8 μM for MGC-803, HeLa, NCI-H460, HepG2, SMMC-7721, T-24 and HL-7702 cells, respectively.

Cell Cycle Analysis^[1]

Cell Line:

MGC-803 and T-24 cell lines
Concentration:

0, 8 and 12 μM
Incubation Time:

24 hours
Result:

Significantly induced cell cycle arrest at the G2/M phase in T-24 cells.

Western Blot Analysis^[1]

Cell Line:

MGC-803 and T-24 cell lines
Concentration:

4, 8 and 12 μM
Incubation Time:

24 hours
Result:

Decreased expression level of cyclin B1.

Apoptosis Analysis^[1]

Cell Line:

MGC-803 and T-24 cell lines
Concentration:

0, 4, 8 and 16 μM
Incubation Time:

24 hours
Result:

Induced cell apoptosis of T-24 cells from 8.21 to 32.91% after treatment by increasing levels of caspase-3 and caspase-9 in T-24 cells.

Chemical Information

CAS. Nr. 2222930-76-7
Molecular Weight 433.45
Formel C₂₄H₂₁F₂N₅O
SMILES

CC1=CC(C)=CC(NC(NC2=CC=CC(CNC3=NC4=CC(F)=C(C=C4N=C3)F)=C2)=O)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li GZ, et al. Synthesis and biological evaluation of novel 1,3-diphenylurea quinoxaline derivatives as potent anticancer agents. Med Chem Res 30, 1496–1511 (2021).

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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