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Art. -Nr.: HY-155402

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Antiproliferative agent-42

Antiproliferative agent-42 (compound 7m) is a dihydrodipyrrolo compound. Antiproliferative agent-42 showed antiproliferative activity against Panc-1 cell line with an IC₅₀ value of 12.54 μM.

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CAS. Nr.: 3002404-74-9
Formel: C₁₈H₁₃N₅O₄
Molecular Weight:363.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

Antiproliferative agent-42 Chemical Structure

CAS. Nr.: 3002404-74-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

Antiproliferative agent-42 (compound 7m) is a dihydrodipyrrolo compound. Antiproliferative agent-42 showed antiproliferative activity against Panc-1 cell line with an IC₅₀ value of 12.54 μM^[1].

Alle Caspase Isoform-spezifische Produkte anzeigen :

In Vitro

Antiproliferative agent-42 (0-100 μM, 48 h) can inhibit Panc-1 and PC3 as well as MDA-MB-231 cell lines with IC₅₀ values of 12.5 μM, 17.7 μM, and 13.1 μM, respectively^[1].
Antiproliferative agent-42 (12.54 μM, 48 h) can induce sub-G1 phase arrest in Panc-1 cancer cells^[1].
Antiproliferative agent-42 (12.54 μM) turns down the protein lever of cleaved-caspase-3 and caspase-3 in Panc-1 cancer cells, while the protein lever of pro-caspase-3 retains unchanged in Panc-1 cancer cells ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

Panc-1
Concentration:

12.54 μM
Incubation Time:

48 h
Result:

Induced apoptosis at 15.54 μM concentration (11.1%).

Chemical Information

CAS. Nr. 3002404-74-9
Molecular Weight 363.33
Formel C₁₈H₁₃N₅O₄
SMILES

O=C1NNC(C2=C1C(C3=CC([N+]([O-])=O)=CC=C3)=C4N2CCN5C4=CC=C5)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lish A B,et al. Synthesis and Biological Evaluation of 12-Aryl-11-hydroxy-5,6-dihydropyrrolo[2″,1″:3′,4′]pyrazino[1′,2′:1,5]pyrrolo[2,3‑d]pyridazine-8(9H)‑one Derivatives as Potential Cytotoxic Agents [J].[2023-11-08].

[2]. Barghi Lish, Azam, et al. "Synthesis and Biological Evaluation of 12-Aryl-11-hydroxy-5, 6-dihydropyrrolo [2 ″, 1 ″: 3′, 4′] pyrazino [1′, 2′: 1, 5] pyrrolo [2, 3-d] pyridazine-8 (9 H)-one Derivatives as Potential Cytotoxic Agents." ACS Omega (2023).

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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