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Art. -Nr.: HY-161814

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Apoptosis inducer 20

Apoptosis inducer 20 (12) causes G2/M cell cycle arrest and induction of apoptosis via caspase 3/7 activation, which occurred during M arrest. Apoptosis inducer 20 is a novel indolic benzenesulfonamide with anti-proliferative effect against a broad panel of cancer cell lines, which is proming for research of new anti-mitotic agents.

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Formel: C₂₀H₂₁N₃O₅S
Molecular Weight:415.46

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Apoptosis inducer 20 Chemical Structure

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	22.1 nM Compound: 12	Antiproliferative activity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay Antiproliferative activity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay	[PMID: 38959729]
BT-474	IC₅₀	68.3 nM Compound: 12	Antiproliferative activity against human BT-474 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay Antiproliferative activity against human BT-474 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay	[PMID: 38959729]
CAKI-1	IC₅₀	56.2 nM Compound: 12	Antiproliferative activity against human CAKI-1 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay Antiproliferative activity against human CAKI-1 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay	[PMID: 38959729]
HEK293	IC₅₀	23.4 nM Compound: 12	Antiproliferative activity against human HEK293 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay Antiproliferative activity against human HEK293 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay	[PMID: 38959729]
HeLa	IC₅₀	1.7 nM Compound: 12	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38959729]
HeLa	IC₅₀	11 nM Compound: 12	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay	[PMID: 38959729]
HeLa	IC₅₀	16.3 nM Compound: 12	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs in presence of verapamil by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs in presence of verapamil by MTT assay	[PMID: 38959729]
HeLa	IC₅₀	22.3 nM Compound: 12	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs in absence of verapamil by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs in absence of verapamil by MTT assay	[PMID: 38959729]
HT-1080	IC₅₀	9.9 nM Compound: 12	Antiproliferative activity against human HT-1080 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay Antiproliferative activity against human HT-1080 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay	[PMID: 38959729]
MCF7	IC₅₀	13.7 nM Compound: 12	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay	[PMID: 38959729]
MDA-MB-468	IC₅₀	13 nM Compound: 12	Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay Antiproliferative activity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay	[PMID: 38959729]
MES-SA	IC₅₀	8.9 nM Compound: 12	Antiproliferative activity against human MES-SA cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay Antiproliferative activity against human MES-SA cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay	[PMID: 38959729]
TERT-RPE1	IC₅₀	80.4 nM Compound: 12	Antiproliferative activity against human RPE-1 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay Antiproliferative activity against human RPE-1 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay	[PMID: 38959729]

In Vitro

Apoptosis inducer 20 inhibits cell growth activity in different cancer cell lines. The melanoma cell-line MelMet5 is the most sensitive cell-line, followed by HeLa^[1].
Apoptosis inducer 20 (100 nM, 24 h) causes G2/M cell cycle arrest and induction of apoptosis via caspase 3/7 activation in MES-SA cells^[1].

Antiproliferative IC50 values of active sulfonamides on HeLa, MCF7, BT-474, MDA-MB468, MES-SA, HT-1080, MelMet5, A375, WM-1366, and Caki1 cancer cell lines^[1]

	HeLa	MCF7	BT-474	MDA-MB468	MES-SA	HT-1080	MelMet5	A375	WM-1366	Caki1
12	11.0	13.7	68.3	13.0	8.9	9.9	8.9	22.1	52.8	56.2

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

MES-SA cells (human uterine sarcoma)
Concentration:

100 nM
Incubation Time:

24 h
Result:

Increased the percentage of cells in the G2/M ensemble from 13.3 % to 83.6-89.7 % at the expense of the S (from 27 % to 6-9 %) and G1 phases (from 60 % to 4-7 %) in MES-SA cells.

Apoptosis Analysis^[1]

Cell Line:

MES-SA cells (human uterine sarcoma)
Concentration:

100 nM
Incubation Time:

3 days
Result:

Induced caspase activation and therefore cell apoptosis in a time-dependent manner in MES-SA cells.

Immunofluorescence^[1]

Cell Line:

MES-SA cells (human uterine sarcoma)
Concentration:

10 nM
Incubation Time:

24 h
Result:

Induced microtubule nonfunction, depolymerization and the cell loseed its characteristic shape in MES-SA cells.

Chemical Information

Molecular Weight 415.46
Formel C₂₀H₂₁N₃O₅S
SMILES

CN1C=CC2=C1C=CC(N(CC#N)S(C3=CC(OC)=C(OC)C(OC)=C3)(=O)=O)=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Fuentes-Martín R, et al. Promising anti-proliferative indolic benzenesulfonamides alter mechanisms with sulfonamide nitrogen substituents[J]. Eur J Med Chem. 2024 Sep 5;275:116617. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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