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Art. -Nr.: HY-159096

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Apoptosis inducer 21

Apoptosis inducer 21 (Compound 5h) inhibits the proliferation of lung cancer cell H69AR with an IC₅₀ of 1.58 μM. Apoptosis inducer 21 arrests the cell cycle at G0/G1 phase, induces apoptosis in H69AR.

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Formel: C₃₈H₂₉Br₂NO₆
Molecular Weight:755.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Apoptosis inducer 21 Chemical Structure

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	21.19 μM Compound: 5h	Antiproliferative activity against human A549 cells by SRB assay Antiproliferative activity against human A549 cells by SRB assay	[PMID: 38964518]
H69AR	IC₅₀	1.58 μM Compound: 5h	Antiproliferative activity against human NCI-H69AR cells by SRB assay Antiproliferative activity against human NCI-H69AR cells by SRB assay	[PMID: 38964518]
NCI-H358	IC₅₀	35.82 μM Compound: 5h	Antiproliferative activity against human NCI-H358 cells by SRB assay Antiproliferative activity against human NCI-H358 cells by SRB assay	[PMID: 38964518]

Chemical Information

Molecular Weight 755.45
Formel C₃₈H₂₉Br₂NO₆
SMILES

CC1=C(O)C(CC(N2)=C(CC3=C(O)C(C(C4=CC=C(Br)C=C4)=O)=CC(C)=C3O)C5=C2C=CC=C5)=C(O)C(C(C6=CC=C(Br)C=C6)=O)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lin J, et al., Synthesis and biological evaluation of novel penindolone derivatives as potential antiproliferative agents against SCLC in vitro. Bioorg Med Chem Lett. 2024 Jul 2;110:129877. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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