AZ12253801
AZ12253801 is an ATP-competitive IGF-1R tyrosine kinase inhibitor that shows ∼10-fold selectivity over the insulin receptor. AZ12253801 inhibits IGF-1R–driven proliferation in 3T3 mouse fibroblasts (transfected with human IGF-1R) with an IC50 of 17 nmol/L. The IC50 for epidermal growth factor receptor (EGFR)–driven proliferation is 440 nmol/L. Anti-tumor activity.
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- CAS. Nr.: 851432-37-6
- Formel: C21H22N8O
- Molecular Weight:402.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Chemical Information
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CAS. Nr. 851432-37-6
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Molecular Weight 402.45
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Formel C21H22N8O
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SMILES
[H][C@](CCC1)(C2=CC(C3=CC=CC=N3)=NO2)N1C4=NC(C)=CC(NC5=NNC(C)=C5)=N4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AZ12253801 Related Classifications
HY-125102 Related Classifications
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