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Art. -Nr.: HY-167671

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BE-10988

BE-10988 is a DNA topoisomerase inhibitor. BE-10988 inhibits the growth of Doxorubicin (HY-15142A)-resistant and vincristine-resistant P388 mouse leukemia cell lines by increasing the formation of DNA topoisomerase complexes.

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CAS. Nr.: 135261-89-1
Formel: C₁₃H₁₀N₄O₃S
Molecular Weight:302.31

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

BE-10988 Chemical Structure

CAS. Nr.: 135261-89-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Topoisomerase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
SK-BR-3	IC₅₀	8.7 μM Compound: 1	The IC50 value was measured on human breast cancer cell line SK-BR-3. The IC50 value was measured on human breast cancer cell line SK-BR-3.	[PMID: 7699696]
V79	IC₅₀	5.1 μM Compound: 1	The IC50 value was measured on V79 cells in the presence of nitrogen using MTT assay. The IC50 value was measured on V79 cells in the presence of nitrogen using MTT assay.	[PMID: 7699696]
V79	IC₅₀	6.2 μM Compound: 1	The IC50 value was measured on V79 cells in the presence of air using MTT assay. The IC50 value was measured on V79 cells in the presence of air using MTT assay.	[PMID: 7699696]

Chemical Information

CAS. Nr. 135261-89-1
Molecular Weight 302.31
Formel C₁₃H₁₀N₄O₃S
SMILES

O=C(C1=CSC(C2=CN(C)C(C(C=C3N)=O)=C2C3=O)=N1)N
Structure Classification
- Quinones
- Benzene Quinones
Initial Source
- Microorganism
Actinomycetes
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Oka H, et al. A NEW TOPOISOMERASE-II INHIBITOR, BE-10988, PRODUCED BY A STREPTOMYCETE I. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION[J]. The Journal of Antibiotics, 1991, 44(5): 486-491. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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