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Art. -Nr.: HY-10335

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BMS-645737

BMS-645737 is an orally active, selective FGF receptor-1 and VEGF receptor-2 inhibitor. BMS-645737 selectively and competitively inhibits both VEGFR-2 and FGFR-1 tyrosine kinases. BMS-645737 has anti-angiogenic activity. BMS-645737 induces lesions in the incisor teeth.

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CAS. Nr.: 651744-16-0
Formel: C₂₀H₂₀N₈O
Molecular Weight:388.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BMS-645737 Chemical Structure

CAS. Nr.: 651744-16-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

FGFR1

VEGFR2

Alle VEGFR Isoform-spezifische Produkte anzeigen :

Alle FGFR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
GTL 16 cell line	IC₅₀	>10 μM Compound: 13, BMS-645737	Antitumor activity against human GTL16 cells Antitumor activity against human GTL16 cells	[PMID: 18395443]
HUVEC	IC₅₀	13 nM Compound: 13, BMS-645737	Antiproliferative activity against VEGF-induced HUVEC Antiproliferative activity against VEGF-induced HUVEC	[PMID: 18395443]
HUVEC	IC₅₀	138 nM Compound: 13, BMS-645737	Antiproliferative activity against bFGF-induced HUVEC Antiproliferative activity against bFGF-induced HUVEC	[PMID: 18395443]
L2987	IC₅₀	>2500 nM Compound: 13, BMS-645737	Antitumor activity against human L2987 cells xenografted in mouse Antitumor activity against human L2987 cells xenografted in mouse	[PMID: 18395443]
NCI-N87	IC₅₀	>10 μM Compound: 13, BMS-645737	Antitumor activity against human N87 cells Antitumor activity against human N87 cells	[PMID: 18395443]

Chemical Information

CAS. Nr. 651744-16-0
Molecular Weight 388.44
Formel C₂₀H₂₀N₈O
SMILES

N=1N=C(OC1C2=CN3N=CN=C(NC=4C=NC=5NC(=CC5C4)C)C3=C2C(C)C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Fletcher AM, et al. Incisor degeneration in rats induced by vascular endothelial growth factor/fibroblast growth factor receptor tyrosine kinase inhibition. Toxicol Pathol. 2010 Feb;38(2):267-79. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
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BMS-645737

Alle VEGFR Isoform-spezifische Produkte anzeigen

Alle FGFR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

Cellular Effect

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

BMS-645737 Related Classifications

HY-10335 Related Classifications

Bioz

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