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Art. -Nr.: HY-125197

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BRD5631

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production.

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CAS. Nr.: 2446154-91-0
Formel: C₃₀H₃₅N₃O₄
Molecular Weight:501.62

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

BRD5631 Chemical Structure

CAS. Nr.: 2446154-91-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Autophagy^[1]

In Vitro

BRD5631 (10 μM, 48 hours) leads to increased levels of LC3-II in HeLa cells. BRD5631 stimulates formation of new autophagosomes, which is consistent with its ability to increase numbers of autolysosomes in the mCherry-GFP-LC3 assay^[1].
BRD5631 does not enhance autophagy by directly inhibiting mTOR or the mTOR signaling pathway. BRD5631 suppressed IL-1β secretion in an autophagy-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HeLa cells.
Concentration:

10 μM.
Incubation Time:

48 hours.
Result:

Led to increased levels of LC3-II.

Chemical Information

CAS. Nr. 2446154-91-0
Molecular Weight 501.62
Formel C₃₀H₃₅N₃O₄
SMILES

O=C(NC1=CC=C2C(C(N(C[C@@H](OC)[C@@H](C)CN[C@@H](C)CO2)C)=O)=C1)C3=CC=C(C4=CC=CC=C4)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Cancer Gene Ther

miR-219-5p attenuates cisplatin resistance of ovarian cancer by inactivating Wnt/β-catenin signaling and autophagy via targeting HMGA2. [Abstract]

2023 Apr;30(4):596-607. PMID: 36494581

BRD5631 purchased from MedChemExpress. Usage Cited in: Cancer Gene Ther. 2023 Apr;30(4):596-607. [Abstract]

Both HLY78 and BRD5631 significantly abrogate the effects of miR-219-5p on SKOV3 and SKOV3/DDP cell invasion (fig E) and migration (fig F).

BRD5631 purchased from MedChemExpress. Usage Cited in: Cancer Gene Ther. 2023 Apr;30(4):596-607. [Abstract]

Both HLY78 and BRD5631 significantly abrogate the effect of miR-219-5p on SKOV3 and SKOV3/DDP cell apoptosis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kuo SY, et al. Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4281-7. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

BRD5631

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
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Publications (1)
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1/16
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BRD5631 purchased from MedChemExpress. Usage Cited in: Cancer Gene Ther. 2023 Apr;30(4):596-607. [Abstract]

Customer Validation
Both HLY78 and BRD5631 significantly abrogate the effects of miR-219-5p on SKOV3 and SKOV3/DDP cell invasion (fig E) and migration (fig F).
1/16

BRD5631 purchased from MedChemExpress. Usage Cited in: Cancer Gene Ther. 2023 Apr;30(4):596-607. [Abstract]

Customer Validation
Both HLY78 and BRD5631 significantly abrogate the effect of miR-219-5p on SKOV3 and SKOV3/DDP cell apoptosis.

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BRD5631

Publications Citing Use of MedChemExpress (MCE) BRD5631

Biologische Aktivität

Chemical Information

Publications (1)

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BRD5631 Related Classifications

HY-125197 Related Classifications