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Art. -Nr.: HY-181989

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CAIF

CAIF is an irreversible, selective allosteric covalent inhibitor of ucosyltransferase 8 (FUT8) with an IC₅₀ of 5.7 μM. CAIF inhibits core fucosylation modification in cancer cells, and suppresses the invasion and migration of cancer cells. CAIF is applicable for cancer research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₇H₄₆BrN₃O₄
Molecular Weight:556.58

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

CAIF Chemical Structure

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

CAIF (0-500 μM; 72 h) exhibits extremely low cytotoxicity in HeLa, A375, GAK and HEK293T cells, with no toxicity detected at the concentration of 500 μM in HeLa and GAK cells^[1].
CAIF (0-300 μM; 72 h) significantly inhibits core fucosylation in HeLa, A375 and GAK cells, with an EC₅₀ of 38.4 μM in GAK cells^[1].
CAIF (1-100 μM; 72 h) inhibits the invasion of HeLa cells in vitro, and its efficacy is superior to that of 2FF at the tested concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Invasion Assay^[1]

Cell Line:

HeLa
Concentration:

1, 10, 50, 100 μM
Incubation Time:

48 h (pretreatment); 24 h (invasion assay incubation at 37 °C)
Result:

Outperformed 2FF in suppressing HeLa cell migration and invasion in the in vitro invasion assay.

Chemical Information

Molecular Weight 556.58
Formel C₂₇H₄₆BrN₃O₄
SMILES

C[N+]1=C(C)N(C=C1)CCCCCCCCCCCCCCCCCC(ON2C(CCC2=O)=O)=O.[Br-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Jiang J, et al. Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression. Nat Commun. 2026 Feb 10;17(1):2607.
[Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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