77-39-4
Chemical Structure
Cycrimine
- CAS. Nr.: 77-39-4
- Formula:C19H29NO
- Molecular Weight:287.44
IUPAC Name: 1-cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol
InChIKey: SWRUZBWLEWHWRI-UHFFFAOYSA-N
SMILES: OC(C1CCCC1)(C2=CC=CC=C2)CCN3CCCCC3
Biological Activity: Cycrimine is an orally active muscarinic cholinergic receptor (mAChR) M1 antagonist, reduces the acetylcholine levels in parkinson model. Cycrimine shows antispasmodic activity, can be used in studies of behavioral and mental disorder[1][2][3][4].
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Cycrimine | 99.85% | Cycrimine is an orally active muscarinic cholinergic receptor (mAChR) M1 antagonist, reduces the acetylcholine levels in parkinson model. Cycrimine shows antispasmodic activity, can be used in studies of behavioral and mental disorder. | ||||||||||||||||||||
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Similarity Score 0.99
HY-B1487AProcyclidine -
Similarity Score 0.97
HY-B1487Procyclidine hydrochloride -
Similarity Score 0.97
HY-B1277ATrihexyphenidyl -
Similarity Score 0.95
HY-B1277Trihexyphenidyl hydrochloride -
Similarity Score 0.75
HY-B1806ATridihexethyl chloride -
Similarity Score 0.73
HY-129709DAC 5945 -
Similarity Score 0.71
HY-145391Triperiden -
Similarity Score 0.71
HY-13204ABiperiden -
Similarity Score 0.70
HY-13204Biperiden hydrochloride -
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References
- [1]. David T. CHAU. Methods of treating behaviorial and/or mental disorders. WO2014176460A1.
- [2]. Marzoughi S, et al. Tardive neurotoxicity of anticholinergic drugs: A review. J Neurochem. 2021 Sep;158(6):1334-1344. [Content Brief]
- [3]. Tacke, et al. Syntheses and pharmacological characterization of achiral and chiral enantiopure C/Si/Ge-analogous derivatives of the muscarinic antagonist cycrimine: a study on C/Si/Ge bioisosterism. Journal of organometallic chemistry 640.1-2 (2001): 140-
- [4]. MAGEE KR, et al. Antispasmodic compound 08958 in treatment of paralysis agitans. J Am Med Assoc. 1953 Oct 24;153(8):715-8. [Content Brief]