CH1055-PEG
CH1055-PEG is a water-soluble PEG-modified second near-infrared (NIR-II) small-molecule fluorescent dye. CH1055-PEG can be used in studies such as in vivo fluorescence imaging, tumor-targeted tracing, lymph node imaging, and image-guided surgery (λAbs/λem : 750/1055 nm).
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- CAS. Nr.: 1988753-67-8
- Formel: (C2H4O)44(C2H4O)44(C2H4O)44(C2H4O)44C66H72N10O8S2
- Molecular Weight:8950.81
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
In Vitro
CH1055-PEG exhibits photostability in water, PBS, and serum[6].
CH1055-PEG (up to 1.5 mM; 36 h) shows no observable cytotoxicity in U87MG cells in the MTS assay[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
CH1055-PEG (100 μg; i.v.; single dose) enables non-invasive, high-definition cerebrovascular imaging in female C57BL/6 mice[6].
CH1055-PEG (300 μM, 10 μL; s.c.; single dose; 24 h) enables sentinel lymph node and lymphatic vessel imaging and, over time, passive tumor-targeted imaging in immunodeficient nude mice bearing shoulder U87MG xenograft tumors[6].
CH1055-PEG (100 μg; i.v.; single dose; 72 h) enables clear imaging of deep brain tumors through the intact scalp and skull in an orthotopic nude mouse glioma model[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice (8-week-old; male)[6]
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Dosage:100 μg
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Administration:i.v.; single dose; monitored continuously for 24 h
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Result:Generated a strong fluorescence signal in the bladder within a few minutes after injection, while the liver exhibited only weak fluorescence.
Excreted approximately 90% of the injected dose through urine within 24 hours, demonstrating excellent rapid renal clearance characteristics.
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Animal Model:immunodeficient nude mice inoculated with U87MG cells subcutaneously on the shoulder to build xenografts[6]
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Dosage:10 μL (300 μM)
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Administration:s.c.; single dose; monitored continuously for 24 h
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Result:Clearly visualized lymphatic vessels and inguinal lymph nodes immediately after injection with an extremely high signal-to-background ratio and very low background scattering.
Began to accumulate and emit fluorescence in the tumor at 5-7 hours post-injection, and the tumor fluorescence became extremely prominent after 24 hours, achieving passive targeted long-term imaging of the tumor.
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Animal Model:nude mice (8-week-old; female) were stereotactically injected with U87MG cells at a depth of 2.5-4 mm in the left brain hemisphere to build orthotopic glioblastoma[6]
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Dosage:100 μg
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Administration:i.v.; single dose; monitored continuously for 72 h
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Result:Successfully penetrated the intact scalp and skull to clearly display the deep brain tumor 6 hours after injection, with a signal-to-background ratio of 3.2.
Achieved a tumor-to-normal tissue signal ratio of 5.50 after 72 hours, realizing high-contrast non-invasive imaging.
Chemical Information
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CAS. Nr. 1988753-67-8
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Molecular Weight 8950.81
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Formel (C2H4O)44(C2H4O)44(C2H4O)44(C2H4O)44C66H72N10O8S2
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SMILES
O=C(NCCOC)CCC(C=C1)=CC=C1N(C2=CC=C(C3=C(N=S=N4)C4=C(C5=CC=C(N(C6=CC=C(CCC(NCCOC)=O)C=C6)C7=CC=C(CCC(NCCOC)=O)C=C7)C=C5)C8=NSN=C83)C=C2)C9=CC=C(CCC(NCCOC)=O)C=C9.[44].[44].[44].[44]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[4]. Cai Q, et al. Precise Diagnosis and Therapy of Bone Cancer Using Near-Infrared Lights. Frontiers in bioengineering and biotechnology. 2021;9:771153. [Content Brief]
[5]. Domínguez M, et al. Renal-clearable probes for disease detection and monitoring. Trends in biotechnology. 2025 Jun;43(6):1286-1301. [Content Brief]
[6]. Antaris AL, Chen H, Cheng K, Sun Y, Hong G, Qu C, Diao S, Deng Z, Hu X, Zhang B, Zhang X, Yaghi OK, Alamparambil ZR, Hong X, Cheng Z, Dai H. A small-molecule dye for NIR-II imaging. Nat Mater. 2016 Feb;15(2):235-42. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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