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Art. -Nr.: HY-181933

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Clathrin-IN-5

Clathrin-IN-5 (Compound 9) is a Clathrin N-terminal domain-Amphiphysin protein-protein interaction inhibitor with an IC₅₀ of 2.77 μM. Clathrin-IN-5 inhibits the protein-protein interaction between the clathrin N-terminal domain and amphiphysin. Clathrin-IN-5 inhibits clathrin-mediated endocytosis with an IC₅₀ of 4.6 μM. Clathrin-IN-5 inhibits the GTPase activity of Dynamin I with an IC₅₀ of 29.7 μM.

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CAS. Nr.: 339025-18-2
Formel: C₁₆H₁₀ClNO₃
Molecular Weight:299.71

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Clathrin-IN-5 Chemical Structure

CAS. Nr.: 339025-18-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

Dynamin I

29.7 μM (IC₅₀)

In Vitro

Clathrin-IN-5 potently inhibits the Clathrin N-terminal domain-amphiphysin protein-protein interaction with an IC₅₀ of 2.77 ± 0.9 μM in an ELISA-based binding assay^[1].
Clathrin-IN-5 inhibits clathrin-mediated endocytosis in U2OS osteosarcoma cells with an IC₅₀ of 4.6 ± 0.5 μM^[1].
Clathrin-IN-5 inhibits full-length human dynamin I GTPase activity with an IC₅₀ of 29.7 ± 3.3 μM in an in vitro colorimetric assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 339025-18-2
Molecular Weight 299.71
Formel C₁₆H₁₀ClNO₃
SMILES

OC1=CC(NC(C(C2=C3C=CC=C2)=O)=C(Cl)C3=O)=CC=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. O'Brien NS, et al. DFT guided design of novel quinone bioisosteres as inhibitors of the clathrin N-terminal domain-amphiphysin protein-protein interaction. Dihydroquinazolin-4(1H)-ones and quinazolin-3(4H)-ones. Eur J Med Chem. Published online March 2, 2026. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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