Clofexamide
Clofexamide (ANP 246) is an orally active antidepressant agent, exhibiting analgesic and anti-inflammatory activity. Clofexamide can be used for the research of depression, inflammatory disorders, peptic ulcer.
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- CAS. Nr.: 1223-36-5
- Formel: C14H21ClN2O2
- Molecular Weight:284.78
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male; 300-400 g, 8-week-old)[2]
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Dosage:200 mg/kg
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Administration:p.o.; single dose
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Result:Excreted approximately 85% of the dosed clofexamide in urine within 24 hours, with 36% as unchanged clofexamide, 20% as 2-(p-chlorophenoxy)-N-(2-ethylaminoethyl) acetamide, 7% as 2-(p-chlorophenoxy)-N-(2-aminoethyl) acetamide, 7% as 2-(4-chloro-2-hydroxyphenoxy)-N-(2-diethylaminoethyl) acetamide, 15% as p-chlorophenoxyacetic acid, plus minor amounts of 2-(p-chlorophenoxy)-N-(2-diethylaminoethyl) acetamide N-oxide and p-chlorophenoxyaceturic acid.
Detected additional urinary metabolites including 2-(4-chloro-3-hydroxyphenoxy)-N-(2-diethylaminoethyl) acetamide, 2-(4-chloro-3-hydroxyphenoxy)-N-(2-ethylaminoethyl) acetamide, 2-(4-chloro-2-hydroxyphenoxy)-N-(2-ethylaminoethyl) acetamide.
Detected only unchanged clofexamide in feces.
Chemical Information
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CAS. Nr. 1223-36-5
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Molecular Weight 284.78
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Formel C14H21ClN2O2
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SMILES
CCN(CC)CCNC(COC1=CC=C(Cl)C=C1)=O
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Synonyms
ANP 246; Amichlophene; Chlofexamide
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Kirkpatrick D, et al. Identification of an N-oxide as the major metabolite of the analgesic O-(diethylaminoethyl)-4-chlorobenzaldoxime hydrochloride in dogs. Xenobiotica. 1977 Dec;7(12):747-55. [Content Brief]
[2]. Irino O, et al. Studies on absorption, biotransformation and excretion of drug. 1. Metabolites of clofexamide in rat. Chem Pharm Bull (Tokyo). 1972 Jan;20(1):47-55. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Clofexamide Related Classifications
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