CMX990
Based on 1 Customer Validation
CMX990 is a SARS-CoV-2 3CL protease inhibitor. The EC90s for inhibiting SARS-CoV-2 were 9.6 nM and 101 nM in human bronchial epithelial cells (HBECs) and HeLa-ACE2 cells, respectively. CMX990 has good ADME and pharmacokinetic properties.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 96.63%
- CAS. Nr.: 2882934-64-5
- Formel: C22H32F3N3O6
- Molecular Weight:491.50
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
SARS-CoV-2[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Epithelial cell | EC50 |
5.3 nM
Compound: CMX990
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Antiviral activity against SARS-CoV-2 infected in human Primary bronchial epithelial cell assessed as inhibition of viral growth
Antiviral activity against SARS-CoV-2 infected in human Primary bronchial epithelial cell assessed as inhibition of viral growth
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[PMID: 38335279] |
| HCT-8 | CC50 |
>30 μM
Compound: CMX990
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Cytotoxicity against human HCT-8 cells incubated for 120 hrs by Cell-Titer Glo assay
Cytotoxicity against human HCT-8 cells incubated for 120 hrs by Cell-Titer Glo assay
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[PMID: 38335279] |
| HeLa | CC50 |
>40 μM
Compound: CMX990
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Cytotoxicity against human HeLa cells expressing ACE2 incubated for 120 hrs by Cell-Titer Glo assay
Cytotoxicity against human HeLa cells expressing ACE2 incubated for 120 hrs by Cell-Titer Glo assay
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[PMID: 38335279] |
| MRC5 | CC50 |
>30 μM
Compound: CMX990
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Cytotoxicity against human MRC5 cells incubated for 120 hrs by Cell-Titer Glo assay
Cytotoxicity against human MRC5 cells incubated for 120 hrs by Cell-Titer Glo assay
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[PMID: 38335279] |
Chemical Information
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CAS. Nr. 2882934-64-5
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Appearance Solid
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Molecular Weight 491.50
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Formel C22H32F3N3O6
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Color White to off-white
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SMILES
O=C(N[C@H](C(COC(F)(F)F)=O)C[C@@H]1CCNC1=O)[C@@H]2CC3(CC3)CN2C([C@H](O)CC(C)C)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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