COX-2-IN-14
COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice.
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- CAS. Nr.: 2428387-48-6
- Formel: C18H18N4O6
- Molecular Weight:386.36
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
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COX-2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774.A1 | CC50 |
<100 μM
Compound: 2a
|
Cytotoxicity against mouse J774A1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against mouse J774A1 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 32503692] |
| L929 | CC50 |
257.42 μM
Compound: 2a
|
Cytotoxicity against mouse L929 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against mouse L929 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
|
[PMID: 32503692] |
Chemical Information
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CAS. Nr. 2428387-48-6
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Molecular Weight 386.36
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Formel C18H18N4O6
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SMILES
CCOC(C1=C(C=C(C([O-])=N1)C#N)C(C2=CC=C(C=C2)[N+]([O-])=O)=O)=O.C[NH2+]C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)