CP-100356
Based on 9 publication(s) in Google Scholar
CP-100356 is an orally active dual MDR1 (P-gp)/BCRP inhibitor, with an IC50s of 0.5 and 1.5 µM for inhibiting MDR1-mediated Calcein-AM transport and BCRP-mediated Prazosin transport, respectively. CP-100356 is also a weak inhibitor of OATP1B1 (IC50 = ∼66 µM). CP-100356 is devoid of inhibition against MRP2 and major human P450 enzymes (IC50 > 15 µM).
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- CAS. Nr.: 142716-85-6
- Formel: C31H36N4O6
- Molecular Weight:560.64
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) CP-100356
More- J Med Chem. 2024 May 16. [Abstract]
- Commun Med (Lond). 2025 Apr 26;5(1):140. [Abstract]
- Molecules. 2025 Jan 17;30(2):387. [Abstract]
- Antimicrob Agents Chemother. 2025 Apr 2;69(4):e0155624. [Abstract]
- SLAS Discov. 2024 May 16:100160. [Abstract]
- bioRxiv. 2025 Nov 3.
- Res Sq. 2024 Nov 25.
- Preprints. 2024 Jan 3.
- Preprints. 2022, 2022050381.
Biologische Aktivität
Chemical Information
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CAS. Nr. 142716-85-6
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Molecular Weight 560.64
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Formel C31H36N4O6
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SMILES
COC1=CC2=NC(NCCC3=CC=C(C(OC)=C3)OC)=NC(N4CC5=C(CC4)C=C(C(OC)=C5)OC)=C2C=C1OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (9)
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Journal Impact Factor
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Most Recent
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J Med Chem
Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs. [Abstract]2024 May 16. PMID: 38753594 -
Commun Med (Lond)
Targeted protein degraders of SARS-CoV-2 Mpro are more active than enzymatic inhibition alone with activity against nirmatrelvir resistant virus. [Abstract]2025 Apr 26;5(1):140. PMID: 40287552 -
Molecules
Antiviral Activity and Underlying Mechanism of Moslae herba Aqueous Extract for Treating SARS-CoV-2. [Abstract]2025 Jan 17;30(2):387. PMID: 39860255 -
Antimicrob Agents Chemother
Potent antiviral activity of simnotrelvir against key epidemic SARS-CoV-2 variants with a high resistance barrier. [Abstract]2025 Apr 2;69(4):e0155624. PMID: 40062859 -
SLAS Discov
2024 May 16:100160. PMID: 38761981 -
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Reinheit & Dokumentation
Verweise
[1]. Kalgutkar AS, et, al. N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in the rat. J Pharm Sci. 2009 Dec;98(12):4914-27. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CP-100356 Related Classifications
HY-108347A Related Classifications
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